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Detailed characterization of the polymers revealed a well\u2010defined and highly stable helical conformation of the polyimine backbone responsible for the formation of rodlike structures of over one hundred nanometers. The 4<jats:sub>1<\/jats:sub> helix is further stabilized by \u03b2\u2010sheet\u2010like interactions between the peptide arms. As a result, the cysteine sulfur atoms are regularly aligned along the polymer axis, which provides a unique platform for the scaffolding of various entities by using versatile click\u2010chemistry postmodification approaches. For instance, pyrene derivatives were introduced through thio\u2010specific reactions involving either maleimide, iodoacetamide, or thioester groups, leading to arrays of stacked chromophores with excimer\u2010like emission. A water\u2010soluble cysteine\u2010rich polyisocyanide was successfully biotinylated and coupled to streptavidin.<\/jats:p>","DOI":"10.1002\/chem.200903502","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T12:04:52Z","timestamp":1272629092000},"page":"6176-6186","source":"Crossref","is-referenced-by-count":24,"title":["Cysteine\u2010Containing Polyisocyanides as Versatile Nanoplatforms for Chromophoric and Bioscaffolding"],"prefix":"10.1002","volume":"16","author":[{"given":"St\u00e9phane","family":"Le\u2005Gac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Koepf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen\u2005J.\u2005L.\u2005M.","family":"Cornelissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan\u2005E.","family":"Rowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roeland\u2005J.\u2005M.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,25]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr980027p"},{"key":"e_1_2_6_2_2","volume-title":"Calixarenes An Introduction","author":"Gutsche C. 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