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As a result, the development of ultrasensitive sensing technology for detection and new approaches for the treatment of infectious bacterial pathogens that do not rely on traditional therapeutic regimes is very urgent for public health, food safety, and the world economy. Driven by this need, we report herein a nanotechnology\u2010driven approach that uses antibody\u2010conjugated oval\u2010shaped gold nanoparticles to selectively target and destroy pathogenic bacteria. Our experiments have shown the use of a simple colorimetric assay, with an anti\u2010salmonella antibody conjugated to oval\u2010shaped gold nanoparticles, for the label\u2010free detection of <jats:italic>S.\u2005typhimurium<\/jats:italic> with an excellent detection limit (10<jats:sup>4<\/jats:sup>\u2005bacteria per mL) and high selectivity over other pathogens. When bacteria conjugated to oval\u2010shaped gold nanoparticles were exposed to near\u2010infrared radiation, a highly significant reduction in bacterial cell viability was observed due to photothermal lysis. Ideally, this nanotechnology\u2010based assay would have enormous potential for rapid, on\u2010site pathogen detection to avoid the distribution of contaminated foods.<\/jats:p>","DOI":"10.1002\/chem.201000176","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T12:34:44Z","timestamp":1271334884000},"page":"5600-5606","source":"Crossref","is-referenced-by-count":154,"title":["Rapid Colorimetric Identification and Targeted Photothermal Lysis of <i>Salmonella<\/i> Bacteria by Using Bioconjugated Oval\u2010Shaped Gold Nanoparticles"],"prefix":"10.1002","volume":"16","author":[{"given":"Shuguang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant\u2005K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulal","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adria","family":"Neely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh\u2005C.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,7]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","unstructured":"http:\/\/www.cdc.gov\/NARMS;"},{"key":"e_1_2_6_3_2","unstructured":"http:\/\/www.who.int\/topics\/salmonella\/en;"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i6.939"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200902837"},{"key":"e_1_2_6_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902837"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf901181m"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200902090"},{"key":"e_1_2_6_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902090"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja056428l"},{"key":"e_1_2_6_9_2","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/es703033u"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(199908)79:11<1367::AID-JSFA374>3.0.CO;2-S"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/384397a0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1128\/aem.59.5.1383-1390.1993","volume":"59","author":"Wyatt A.","year":"1993","journal-title":"Appl. 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