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A variety of aromatic, heteroaromatic, \u03b1,\u03b2\u2010unsaturated, and aliphatic aldehydes were found to be suitable substrates in the presence of 2.5\u2005mol\u2009% <jats:sc>L<\/jats:sc>\u2010proline\u2010derived <jats:italic>N,N<\/jats:italic>\u2032<jats:italic>\u2010<\/jats:italic>dioxide <jats:bold>L5<\/jats:bold>\u2013nickel(II) complex. This process was air\u2010tolerant and easily manipulated with available reagents. Based on experimental investigations, a possible transition state has been proposed to explain the origin of reactivity and asymmetric inductivity.<\/jats:p>","DOI":"10.1002\/chem.201000284","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T10:02:02Z","timestamp":1279533722000},"page":"10124-10129","source":"Crossref","is-referenced-by-count":46,"title":["Efficient Synthesis of \u03b2\u2010Hydroxy\u2010\u03b1\u2010Amino Acid Derivatives via Direct Catalytic Asymmetric Aldol Reaction of \u03b1\u2010Isothiocyanato Imide with Aldehydes"],"prefix":"10.1002","volume":"16","author":[{"given":"Xiaohong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingsheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"e_1_2_6_1_2","volume-title":"Glycopeptide Antibiotics","year":"1994"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01054a045"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3050187"},{"key":"e_1_2_6_4_2","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1128\/jb.153.3.1138-1146.1983","volume":"153","author":"Barclay R.","year":"1983","journal-title":"J. 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