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In contrast to the reaction of (PyPepS)<jats:sub>2<\/jats:sub> and DNIC <jats:bold>1<\/jats:bold> in a 1:1 stoichiometry that induces the release of an NO radical and the formation of complex [PPN][Fe(PyPepS)<jats:sub>2<\/jats:sub>] (<jats:bold>4<\/jats:bold>), the incoming substitution ligand (S<jats:sub>2<\/jats:sub>CNMe<jats:sub>2<\/jats:sub>)<jats:sub>2<\/jats:sub> triggered the transformation of DNIC <jats:bold>1<\/jats:bold> into complex [(NO)Fe(S<jats:sub>2<\/jats:sub>CNMe<jats:sub>2<\/jats:sub>)<jats:sub>2<\/jats:sub>] (<jats:bold>2<\/jats:bold>) along with <jats:italic>N<\/jats:italic>\u2010nitrosocarbazole (<jats:bold>3<\/jats:bold>). The subsequent nitrosation of <jats:italic>N<\/jats:italic>\u2010acetylpenicillamine (NAP) by <jats:italic>N<\/jats:italic>\u2010nitrosocarbazole (<jats:bold>3<\/jats:bold>) to produce <jats:italic>S<\/jats:italic>\u2010nitroso\u2010<jats:italic>N<\/jats:italic>\u2010acetylpenicillamine (SNAP) may signify the possible formation pathway of <jats:italic>S<\/jats:italic>\u2010nitrosothiols from DNICs by means of transnitrosation of <jats:italic>N<\/jats:italic>\u2010nitrosamines. Protonation of DNIC <jats:bold>1<\/jats:bold> by [P(SH)<jats:sub>3<\/jats:sub>] triggers the release of HNO and the generation of complex [PPN][Fe(NO)P(C<jats:sub>6<\/jats:sub>H<jats:sub>3<\/jats:sub>\u20103\u2010SiMe<jats:sub>3<\/jats:sub>\u20102\u2010S)<jats:sub>3<\/jats:sub>] (<jats:bold>5<\/jats:bold>). In a similar fashion, the nucleophilic attack of the chelating ligand P(C<jats:sub>6<\/jats:sub>H<jats:sub>3<\/jats:sub>\u20103\u2010SiMe<jats:sub>3<\/jats:sub>\u20102\u2010SNa)<jats:sub>3<\/jats:sub> ([P(SNa)<jats:sub>3<\/jats:sub>]) on DNIC <jats:bold>1<\/jats:bold> resulted in the direct release of [NO]<jats:sup>\u2212<\/jats:sup> captured by [(<jats:sup>15<\/jats:sup>NO)Fe(SPh)<jats:sub>3<\/jats:sub>]<jats:sup>\u2212<\/jats:sup>, thus leading to [(<jats:sup>15<\/jats:sup>NO)(<jats:sup>14<\/jats:sup>NO)Fe(SPh)<jats:sub>2<\/jats:sub>]<jats:sup>\u2212<\/jats:sup>. These results illustrate one aspect of how the incoming substitution ligands ((S<jats:sub>2<\/jats:sub>CNMe<jats:sub>2<\/jats:sub>)<jats:sub>2<\/jats:sub> vs. (PyPepS)<jats:sub>2<\/jats:sub> vs. [P(SH)<jats:sub>3<\/jats:sub>]\/[P(SNa)<jats:sub>3<\/jats:sub>]) in cooperation with the carbazolate\u2010coordinated ligands of DNIC <jats:bold>1<\/jats:bold> function to control the release of NO<jats:sup>+<\/jats:sup>, <jats:sup>.<\/jats:sup>NO, or [NO]<jats:sup>\u2212<\/jats:sup> from DNIC <jats:bold>1<\/jats:bold> upon reaction of complex <jats:bold>1<\/jats:bold> and the substitution ligands. Also, these results signify that DNICs may act as an intermediary of NO in the redox signaling processes by providing the distinct redox\u2010interrelated forms of NO to interact with different NO\u2010responsive targets in biological systems.<\/jats:p>","DOI":"10.1002\/chem.201000524","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T04:38:06Z","timestamp":1275971886000},"page":"8088-8095","source":"Crossref","is-referenced-by-count":43,"title":["Formation of the Distinct Redox\u2010Interrelated Forms of Nitric Oxide from Reaction of Dinitrosyl Iron Complexes (DNICs) and Substitution Ligands"],"prefix":"10.1002","volume":"16","author":[{"given":"Tsai\u2010Te","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Feng","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,12]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1281928"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90269-0"},{"key":"e_1_2_6_4_2","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.10954"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.6017"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.2.1402"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.49.31138"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.4.601"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.35.21767"},{"key":"e_1_2_6_11_2","unstructured":"\u00a0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.052142"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000082524.34487.31"},{"key":"e_1_2_6_14_2","unstructured":"\u00a0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707862200"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-006-0192-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602515103"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2007.12.009"},{"key":"e_1_2_6_19_2","unstructured":"\u00a0"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01354-06"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700490104"},{"key":"e_1_2_6_22_2","unstructured":"\u00a0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00210a047"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80287-6"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10860"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90584-6"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.08.010"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095959"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1569"},{"key":"e_1_2_6_30_2","unstructured":"\u00a0"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306706101"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101723200"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6702"},{"key":"e_1_2_6_34_2","unstructured":"\u00a0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117480"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405987200"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0658259"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406549102"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0233287100"},{"key":"e_1_2_6_40_2","unstructured":"\u00a0"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.3.1223"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9901056"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(99)00021-3"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000076d"},{"key":"e_1_2_6_45_2","first-page":"63","author":"Ueno T.","year":"2002","journal-title":"Biochem. 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