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The use of dichloromethane allows for the activation of two C\uf8ffCl bonds and a clean transfer of the methylene fragment to the final product. The scope of the reaction as well as the influence of different gold(III) cycloaurated complexes and salts has been investigated. The involvement of gold nanoparticles generated in situ in the process is discussed and a plausible reaction mechanism is proposed on the basis of the data obtained.<\/jats:p>","DOI":"10.1002\/chem.201000587","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T10:13:29Z","timestamp":1277460809000},"page":"9287-9296","source":"Crossref","is-referenced-by-count":65,"title":["Mechanistic Insights into the One\u2010Pot Synthesis of Propargylamines from Terminal Alkynes and Amines in Chlorinated Solvents Catalyzed by Gold Compounds and Nanoparticles"],"prefix":"10.1002","volume":"16","author":[{"given":"David","family":"Aguilar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Contel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban\u2005P.","family":"Urriolabeitia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,30]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"Two relevant examples:"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja053408a"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200353583"},{"key":"e_1_2_6_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200353583"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0460763"},{"key":"e_1_2_6_5_2","unstructured":"Copper:"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00121a018"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja993074n"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol017022q"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200204691"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020715)114:14<2651::AID-ANGE2651>3.0.CO;2-1"},{"key":"e_1_2_6_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020715)41:14<2535::AID-ANIE2535>3.0.CO;2-M"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020816)114:16<3180::AID-ANGE3180>3.0.CO;2-L"},{"key":"e_1_2_6_11_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020816)41:16<3054::AID-ANIE3054>3.0.CO;2-B"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/b108851n"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja026007t"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/b110102c"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol049936t"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.08.004"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.09.079"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/b409951f"},{"key":"e_1_2_6_19_2","unstructured":"Silver and gold:"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0359299"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol035781y"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2004.01.044"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-872677"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol0528641"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2008.01.046"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/om801137y"},{"key":"e_1_2_6_27_2","unstructured":"\u00a0"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200800098"},{"key":"e_1_2_6_28_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800098"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2008.12.008"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200900279"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/b702287e"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo048715y"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/c39950000847"},{"key":"e_1_2_6_34_2","unstructured":"Selected examples:"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1039\/C39870001543"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0682(199803)1998:3<349::AID-EJIC349>3.0.CO;2-5"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic010003s"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1039\/dt9940001895"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1039\/c39910000283"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19820940123"},{"key":"e_1_2_6_40_3","first-page":"73","volume":"21","year":"1982","journal-title":"Angew. 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