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As a model analyte, adenosine triphosphate (ATP) is determined by using the DNA machine system in combination with a DNA aptamer recognition strategy and differential pulse anodic stripping voltammetry (DPASV). Under the optimum conditions, detection limits as low as 2.8\u00d710<jats:sup>\u221217<\/jats:sup>\u2009<jats:sc>M<\/jats:sc> (3\u03c3) for target DNA and 4.7\u00d710<jats:sup>\u22129<\/jats:sup>\u2009<jats:sc>M<\/jats:sc> (3\u03c3) for ATP are achieved. The satisfactory determination of ATP in K562 leukemia cell and Ramos Burkitt\u2019s lymphoma cell reveal that this protocol possesses good selectivity and practicality. As a promising biomolecular device, this DNA machine may have an even broader application in the rapidly developing field of nanobiotechnology.<\/jats:p>","DOI":"10.1002\/chem.201000811","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T09:09:47Z","timestamp":1284714587000},"page":"12434-12439","source":"Crossref","is-referenced-by-count":30,"title":["An Autonomous Bio\u2010barcode DNA Machine for Exponential DNA Amplification and Its Application to the Electrochemical Determination of Adenosine 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