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Although ganglioside GalNAc\u2010GD1a was first found as a brain ganglioside, IgG autoantibodies to GalNAc\u2010GD1a were subsequently found to be closely related to a human peripheral\u2010nerve disorder, Guillain\u2013Barr\u00e9 syndrome, which is the commonest cause of acute flaccid paralysis worldwide. In this study, the characteristic hexasaccharide part carrying two sialic acid residues was synthesized efficiently by use of a readily accessible GM2\u2010core unit as a common unit. The potentially difficult coupling of the oligosaccharide and ceramide moieties was carried out by using a cyclic glucosyl ceramide as a coupling partner for the hexasaccharide part, thereby successfully providing the framework of the target compound. Global deprotection delivered the homogenous ganglioside GalNAc\u2010GD1a. 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