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The nanohybrid was synthesized by means of dentate binding of ZnO nanoparticles with carboxylic groups of 4,4\u2032,4\u2032\u2032,4\u2032\u2032\u2032\u2010(21<jats:italic>H<\/jats:italic>,23<jats:italic>H<\/jats:italic>\u2010porphine\u20105,10,15,20\u2010tetrayl)tetrakis(benzoic acid) (TCPP), and characterized with scanning electron microscopy, contact angle measurement, and spectral techniques. The nanohybrid\u2010coated ITO electrode showed an efficient photocurrent response under irradiation at a wavelength of 360\u2005nm, which could be greatly improved upon addition of cysteine by its oxidation at +0.3\u2005V. The possible mechanism was that cysteine acts as a sacrificial electron donor to scavenge the photogenerated holes that locate on the excited state of TCPP, which then injects the photoexcitation electrons into the conduction band of ZnO nanoparticles, thereby transferring photoinduced electrons to the ITO electrode. Based on this enhanced photocurrent signal, a novel method for photoelectrochemical detection of cysteine was developed with a linear range of 0.6 to 157\u2005\u03bcmol\u2009L<jats:sup>\u22121<\/jats:sup> in physiological media. The detection limit was 0.2\u2005\u03bcmol\u2009L<jats:sup>\u22121<\/jats:sup> at a signal\u2010to\u2010noise ratio of 3. The novel strategy of cysteine analysis could provide an alternative method for monitoring biomolecules and extend the application of porphyrin\u2010functionalized semiconductor nanoparticles.<\/jats:p>","DOI":"10.1002\/chem.201100577","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T09:23:15Z","timestamp":1308129795000},"page":"9440-9447","source":"Crossref","is-referenced-by-count":160,"title":["Photoelectrochemistry of Free\u2010Base\u2010Porphyrin\u2010Functionalized Zinc Oxide Nanoparticles and Their Applications in 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