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In addition to the double\u2010stranded configuration, DNA structures also include some non\u2010duplex regions, which are considered to be from spontaneous errors in DNA replication, thus playing an important role for cells. Herein, we focused on these non\u2010duplex regions of DNA and generated manganese(III) corroles, which exhibit a highly selective cleavage ability for guanosine units located at non\u2010duplex portions, such as loops and bulges. The cleavage mechanism was demonstrated to be a manganese\u2010induced oxidation process. The results given herein show a molecular approach that could specifically probe the guanosine units in DNA non\u2010duplex structures, thus representing a promising step in the construction of tools to target non\u2010duplex structures in chromosomes.<\/jats:p>","DOI":"10.1002\/chem.201101128","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T21:53:57Z","timestamp":1308347637000},"page":"8890-8895","source":"Crossref","is-referenced-by-count":11,"title":["Site\u2010Specific Recognition of Guanosine by Manganese(III) Corroles in DNA Non\u2010Duplex Regions through Active Oxygen Transfer"],"prefix":"10.1002","volume":"17","author":[{"given":"Qianqian","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushu","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minggang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,17]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35044005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6199-0_4"},{"key":"e_1_2_6_4_2","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr960421s"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr960428"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar9500877"},{"key":"e_1_2_6_8_2","volume-title":"Principles of Nucleic Acid Structure","author":"Sanger W.","year":"1994"},{"key":"e_1_2_6_9_2","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/363558a0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.7.735"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/b618482k"},{"key":"e_1_2_6_13_2","unstructured":"\u00a0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/b704599a"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200800835"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.200900270"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00014a008"},{"key":"e_1_2_6_18_2","unstructured":"\u00a0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7310086"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182256799"},{"key":"e_1_2_6_21_2","unstructured":"\u00a0"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.9.3967"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.19.3894"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00472a006"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2010.09.005"},{"key":"e_1_2_6_26_2","unstructured":"\u00a0"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja1050296"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja905153r"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc03373a"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja801479y"},{"key":"e_1_2_6_31_2","unstructured":"\u00a0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci800063v"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci9001537"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol048156h"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.2.560"},{"key":"e_1_2_6_36_2","unstructured":"Sybyl Software Version 8.1 St. Louis Tripos Associates Inc. 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