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The efficacy of the metallostar complex as a potential bimodal optical\/magnetic resonance imaging (MRI) agent has been evaluated. Nuclear magnetic relaxation dispersion (NMRD) measurements for the [(Gd<jats:bold>4<\/jats:bold>)<jats:sub>3<\/jats:sub>Ti(H<jats:sub>2<\/jats:sub>O)<jats:sub>3<\/jats:sub>]<jats:sup>5\u2212<\/jats:sup> complex have demonstrated an enhanced <jats:italic>r<\/jats:italic><jats:sub>1<\/jats:sub> relaxivity that corresponds to 36.9\u2005s<jats:sup>\u22121<\/jats:sup>\u2009m<jats:sc>M<\/jats:sc><jats:sup>\u22121<\/jats:sup> per metallostar molecule at 20\u2005<jats:sc>MHz<\/jats:sc> and 310\u2005K, which is a result of a decreased tumbling rate. The ability of the complex to bind to human serum albumin (HSA) was also examined by relaxometric measurements. In addition, upon UV irradiation the [(Gd<jats:bold>4<\/jats:bold>)<jats:sub>3<\/jats:sub>Ti(H<jats:sub>2<\/jats:sub>O)<jats:sub>3<\/jats:sub>]<jats:sup>5\u2212<\/jats:sup> complex exhibits broad\u2010band green emission in the range 400\u2013750\u2005nm with a maximum at 490\u2005nm. Taking into account the high relaxivity and luminescence properties, the [(Gd<jats:bold>4<\/jats:bold>)<jats:sub>3<\/jats:sub>Ti(H<jats:sub>2<\/jats:sub>O)<jats:sub>3<\/jats:sub>]<jats:sup>5\u2212<\/jats:sup> complex is a good lead compound for the development of efficient bimodal contrast agents.<\/jats:p>","DOI":"10.1002\/chem.201101413","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T12:58:42Z","timestamp":1322917122000},"page":"293-302","source":"Crossref","is-referenced-by-count":41,"title":["A Self\u2010Assembled Complex with a Titanium(IV) Catecholate Core as a Potential Bimodal Contrast Agent"],"prefix":"10.1002","volume":"18","author":[{"given":"Geert","family":"Dehaen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana V.","family":"Eliseeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristof","family":"Kimpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luce","family":"Vander\u2005Elst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Dehaen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Binnemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana N.","family":"Parac\u2010Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_1_2","DOI":"10.1021\/cr980440x"},{"volume-title":"The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging","year":"2001","key":"e_1_2_6_2_2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_2","DOI":"10.1039\/b818599a"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_2","DOI":"10.1039\/A827019Z"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_2","DOI":"10.1016\/0079-6565(85)80007-8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_2","DOI":"10.1039\/b510982p"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_2","DOI":"10.1148\/radiology.207.2.9577507"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_2","DOI":"10.1016\/S1076-6332(96)80583-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_2","DOI":"10.1021\/ja017168k"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_2","DOI":"10.1007\/s00249-005-0024-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/BF02668092","volume":"12","author":"Anelli P. 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