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In the presence of two DNA targets, acting as inputs, and appropriate DNA scaffolds, the polymerase\u2010induced replication of the scaffolds, followed by the nicking of the replication products, are activated, leading to the autonomous synthesis of the Mg<jats:sup>2+<\/jats:sup>\u2010dependent DNAzyme or the Mg<jats:sup>2+<\/jats:sup>\u2010dependent DNAzyme subunits. These biocatalysts cleave a fluorophore\/quencher\u2010functionalized nucleic\u2010acid substrate, thus providing fluorescence signals for the sensing events or outputs for the logic gates. The systems are used to develop OR, AND, and Controlled\u2010AND gates, and the DNA\u2010analyte targets represent two nucleic acid sequences of the smallpox viral genome.<\/jats:p>","DOI":"10.1002\/chem.201201995","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T14:20:44Z","timestamp":1348755644000},"page":"14689-14694","source":"Crossref","is-referenced-by-count":58,"title":["Nucleic Acid Driven DNA Machineries Synthesizing Mg<sup>2+<\/sup>\u2010Dependent DNAzymes: An Interplay between DNA Sensing and Logic\u2010Gate Operations"],"prefix":"10.1002","volume":"18","author":[{"given":"Ron","family":"Orbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Mostinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itamar","family":"Willner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,27]]},"reference":[{"key":"e_1_2_5_1_2","unstructured":"\u00a0"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/b807292m"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/b718428j"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2009.01.008"},{"key":"e_1_2_5_5_2","unstructured":"\u00a0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja803507d"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja711192e"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/B815814B"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9062426"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja902951b"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b925168e"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac102719x"},{"key":"e_1_2_5_13_2","unstructured":"\u00a0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl0491428"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/b809296f"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2012.03.013"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac100095u"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-5521(95)90028-4"},{"key":"e_1_2_5_19_2","unstructured":"\u00a0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0386492"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700384"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9076777"},{"key":"e_1_2_5_23_2","unstructured":"\u00a0"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/B615450F"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/b712165b"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200705982"},{"key":"e_1_2_5_26_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705982"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac202643y"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2012.01.024"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200600336"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200602754"},{"key":"e_1_2_5_30_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602754"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2076789"},{"key":"e_1_2_5_32_2","unstructured":"\u00a0"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt862"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi051871u"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200502511"},{"key":"e_1_2_5_35_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502511"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200600525"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)00006-8"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9051075"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201000840"},{"key":"e_1_2_5_39_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201000840"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10262"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2010.88"},{"key":"e_1_2_5_42_2","doi-asserted-by":"crossref","unstructured":"J. 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