{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:14:57Z","timestamp":1770639297632,"version":"3.49.0"},"reference-count":98,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2013,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We demonstrated an asymmetric 1,3\u2010dipolar cycloaddition of azomethine betaines with alkylidene malonates by using a chiral <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010dioxide\u2013Ni<jats:sup>II<\/jats:sup> complex as a catalyst. Both aromatic\u2010 and aliphatic\u2010substituted alkylidene malonates were found to be suitable for the reaction. A range of <jats:italic>trans<\/jats:italic>\u2010pyrazolone derivatives was exclusively obtained with excellent yields (up to 99\u2009% yield) and good enantioselectivities (up to 97\u2009%\u2005<jats:italic>ee<\/jats:italic>) under mild reaction conditions. The reaction could be carried out on a gram scale with the good results being maintained. Control experiments were performed to elucidate the specific diastereoselectivity of the reaction. The formation of single <jats:italic>trans<\/jats:italic> isomers was dominated by secondary orbital interactions between the ester groups of the dipolarophile and the azomethine imine. On the basis of the experimental results and previous reports, a possible catalytic model was assumed.<\/jats:p>","DOI":"10.1002\/chem.201203891","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T10:24:09Z","timestamp":1361960649000},"page":"5134-5140","source":"Crossref","is-referenced-by-count":81,"title":["Nickel(II)\u2010Catalyzed Enantioselective 1,3\u2010Dipolar Cycloaddition of Azomethine Imines with Alkylidene Malonates"],"prefix":"10.1002","volume":"19","author":[{"given":"Jiangting","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjin","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,27]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1071\/CH09074"},{"key":"e_1_2_6_2_2","unstructured":"For synthetic applications of chiral pyrazolones 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