{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:57:36Z","timestamp":1788415056620,"version":"build-2803163510"},"reference-count":109,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2013,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The conversion of an alcohol\u2010based functional group, into a trifluoromethyl analogue is a desirable transformation. However, few methods are capable of converting O\u2010based electrophiles into trifluoromethanes. The copper\u2010mediated trifluoromethylation of benzylic xanthates using Umemoto\u2019s reagent as the source of CF<jats:sub>3<\/jats:sub> to form C\uf8ffCF<jats:sub>3<\/jats:sub> bonds is described. The method is compatible with an array of benzylic xanthates bearing useful functional groups. A preliminary mechanistic investigation suggests that the C\uf8ffCF<jats:sub>3<\/jats:sub> bond forms by reaction of the substrate with in situ generated CuCF<jats:sub>3<\/jats:sub> and CuOTf. Further evidence suggests that the reaction could proceed via a radical cation intermediate.<\/jats:p>","DOI":"10.1002\/chem.201302328","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T15:11:15Z","timestamp":1375801875000},"page":"12800-12805","source":"Crossref","is-referenced-by-count":46,"title":["Copper\u2010Mediated Deoxygenative Trifluoromethylation of Benzylic Xanthates: Generation of a C\uf8ffCF<sub>3<\/sub> Bond from an O\u2010Based Electrophile"],"prefix":"10.1002","volume":"19","author":[{"given":"Lingui","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan 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