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In this research regiospecific site\u2010directed anomerisation is demonstrated. TiCl<jats:sub>4<\/jats:sub> (2.5\u2005equiv) was employed to induce anomerisation of 15 glycosyl azide and disaccharide substrates of low reactivity, and high yields (&gt;75\u2009%) and stereoselectivies (\u03b1\/\u03b2&gt;9:1) were achieved. The examples included glucopyranuronate, galactopyranuronate and mannopyranuronate as well as N\u2010acetylated glucopyranuronate and galactopyranuronate derivatives. A disaccharide with the \u03b11\u21924 linkage found in polygalacturonan was included. The use of benzoylated saccharides was found to be important in disaccharide anomerisation as attempts to isomerise related acetyl protected and 2,3\u2010carbonate protected derivatives were not successful.<\/jats:p>","DOI":"10.1002\/chem.201302572","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T08:00:22Z","timestamp":1381219222000},"page":"14836-14851","source":"Crossref","is-referenced-by-count":20,"title":["Regiospecific Anomerisation of Acylated Glycosyl Azides and Benzoylated Disaccharides by Using TiCl<sub>4<\/sub>"],"prefix":"10.1002","volume":"19","author":[{"given":"Mark","family":"Farrell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul V.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"unstructured":"For recent reviews onO\u2010glycoside synthesis see:","key":"e_1_2_5_1_2"},{"doi-asserted-by":"publisher","key":"e_1_2_5_2_2","DOI":"10.1039\/B916088D"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_2","DOI":"10.1002\/ange.200802036"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_3","DOI":"10.1002\/anie.200802036"},{"unstructured":"\u00a0","key":"e_1_2_5_4_2"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_2","DOI":"10.1021\/jo2017026"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_2","DOI":"10.1038\/nature05819"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_2","DOI":"10.1016\/j.cbpa.2010.02.016"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_2","DOI":"10.1039\/B511197H"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_2","DOI":"10.1002\/ange.201100125"},{"doi-asserted-by":"publisher","key":"e_1_2_5_9_3","DOI":"10.1002\/anie.201100125"},{"unstructured":"\u00a0","key":"e_1_2_5_10_2"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_2","DOI":"10.1021\/ol026629j"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_2","DOI":"10.1002\/ange.200353196"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_3","DOI":"10.1002\/anie.200353196"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_2","DOI":"10.1002\/chem.200601111"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_2","DOI":"10.1016\/j.carres.2006.10.023"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_2","DOI":"10.1021\/jo0501994"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_2","DOI":"10.1021\/jo050200z"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_2","DOI":"10.1021\/ol0484254"},{"key":"e_1_2_5_18_2","first-page":"709","volume-title":"Molecular Rearrangements","author":"Lemieux R. 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