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The immobilized catalyst was highly active and selective, and gave rise to a broad range of 3\u2010indolylmethanamines (19 examples) in high yields and excellent enantioselectivities (up to 98\u2009% enantiomeric excess) after short reaction times under very convenient reaction conditions (RT in dichloromethane). Moreover, repeated recycling (14 cycles) was possible with no substantial loss in catalytic performance and the system could be adapted to a continuous\u2010flow operation (6\u2005h). Finally, the applicability of the system was further confirmed by rapid access to a library of compounds with three points of diversity in a single continuous\u2010flow experiment that involved sequential pumping of different substrate combinations.<\/jats:p>","DOI":"10.1002\/chem.201303860","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T12:42:49Z","timestamp":1390480969000},"page":"2367-2372","source":"Crossref","is-referenced-by-count":101,"title":["Enantioselective Continuous\u2010Flow Production of 3\u2010Indolylmethanamines Mediated by an Immobilized Phosphoric Acid Catalyst"],"prefix":"10.1002","volume":"20","author":[{"given":"Laura","family":"Osorio\u2010Planes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Rodr\u00edguez\u2010Escrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel A.","family":"Peric\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"For reviews see:"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200503132"},{"key":"e_1_2_6_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503132"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200600529"},{"key":"e_1_2_6_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600529"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr068373r"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr068374j"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200704684"},{"key":"e_1_2_6_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200704684"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1218801"},{"key":"e_1_2_6_8_2","unstructured":"For reviews see:"},{"key":"e_1_2_6_9_2","volume-title":"Chiral Catalyst Immobilization and Recycling","year":"2000"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200606096"},{"key":"e_1_2_6_11_2","volume-title":"Handbook of Asymmetric Heterogeneous Catalysis","year":"2008"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/b800704g"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-3696-4_4"},{"key":"e_1_2_6_14_2","unstructured":"\u00a0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200305212"},{"key":"e_1_2_6_16_2","first-page":"209","volume-title":"Topics in Current Chemistry, Vol.\u2005242: Immobilized Catalysts: Solid Phases, Immobilization and Applications","author":"Kirschning A.","year":"2004"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/b405203j"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/b600382f"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200501400"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200600236"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200900970"},{"key":"e_1_2_6_21_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200900970"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470682005.ch13"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200901310"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/op9003136"},{"key":"e_1_2_6_25_2","first-page":"464","author":"Alza E.","year":"2011","journal-title":"Synlett"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc05060a"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201100570"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201200887"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol400974z"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201210066"},{"key":"e_1_2_6_30_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201210066"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3gc40195b"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.200900746"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc43996h"},{"key":"e_1_2_6_34_2","unstructured":"For selected book chapters and publications see:"},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/9780470129661.ch2","volume-title":"The Total Synthesis of Natural Products, Vol.\u20053: The Synthesis of Indole Alkaloids","author":"Kutney J. 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