{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:26:44Z","timestamp":1780622804675,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2014,4,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Owing to their broad spectrum of biological activities and low toxicity, \u03b2\u2010lactams are attractive lead structures for the design of novel molecular probes. However, the synthesis of positron emission tomography (PET)\u2010isotope\u2010labelled \u03b2\u2010lactams has not yet been reported. Herein, we describe the simple preparation of radiofluorinated \u03b2\u2010lactams by using the fast Kinugasa reaction between <jats:sup>18<\/jats:sup>F\u2010labelled nitrone [<jats:sup>18<\/jats:sup>F]\u2010<jats:bold>1<\/jats:bold> and alkynes of different reactivity. Additionally, <jats:sup>18<\/jats:sup>F\u2010labelled fused \u03b2\u2010lactams were obtained through the reaction of a cyclic nitrone <jats:bold>7<\/jats:bold> with radiofluorinated alkynes [<jats:sup>18<\/jats:sup>F]\u2010<jats:bold>6\u2009a<\/jats:bold>,<jats:bold>b<\/jats:bold>. Radiochemical yields of the Kinugasa reaction products could be significantly increased by the use of different Cu<jats:sup>I<\/jats:sup> ligands, which additionally allowed a reduction in the amount of precursor and\/or reaction time. Model radiofluorinated \u03b2\u2010lactam\u2010peptide and protein conjugates ([<jats:sup>18<\/jats:sup>F]\u2010<jats:bold>10<\/jats:bold> and <jats:sup>18<\/jats:sup>F\u2010labelled BSA conjugate) were efficiently obtained in high yield under mild conditions (aq. MeCN, ambient temperature) within a short reaction time, demonstrating the suitability of the developed method for radiolabelling of sensitive molecules such as biopolymers.<\/jats:p>","DOI":"10.1002\/chem.201304056","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T01:48:05Z","timestamp":1394502485000},"page":"4697-4703","source":"Crossref","is-referenced-by-count":26,"title":["Synthesis of <sup>18<\/sup>F\u2010Labelled \u03b2\u2010Lactams by Using the Kinugasa Reaction"],"prefix":"10.1002","volume":"20","author":[{"given":"Boris 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