{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:58:53Z","timestamp":1767999533228,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2014,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new \u03b2\u2010cyclodextrin\u2010based receptor that showed allosteric binding behavior towards capsaicin in aqueous solution was prepared. By NMR titration and nonlinear regression, we obtained binding constants, which increased more than fivefold when an effector (Zn<jats:sup>2+<\/jats:sup>) was bound to a central 2,2\u2032\u2010bipyridine that acts as the allosteric center.<\/jats:p>","DOI":"10.1002\/chem.201403503","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T10:40:26Z","timestamp":1403260826000},"page":"8852-8855","source":"Crossref","is-referenced-by-count":14,"title":["Allosteric Binding of Capsaicin by a Bis(\u03b2\u2010cyclodextrin)\u20102,2\u2032\u2010bipyridine Receptor"],"prefix":"10.1002","volume":"20","author":[{"given":"Christopher","family":"Kremer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"L\u00fctzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"e_1_2_3_1_2","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1961.026.01.048"},{"key":"e_1_2_3_2_2","unstructured":"For some reviews see:"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar00103a006"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac198860040581"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-8545(95)01164-1"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar000177y"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar0000410"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr030673a"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200501476"},{"key":"e_1_2_3_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501476"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201203814"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200801374"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00509a047"},{"key":"e_1_2_3_13_2","unstructured":"\u00a0"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9619600"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(20000303)112:5<975::AID-ANGE975>3.0.CO;2-Q"},{"key":"e_1_2_3_15_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(20000303)39:5<945::AID-ANIE945>3.0.CO;2-E"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo015852b"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/b108121g"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(02)00032-1"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200300389"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200906753"},{"key":"e_1_2_3_20_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906753"},{"key":"e_1_2_3_21_2","unstructured":"\u00a0"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(02)00086-2"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200900642"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.6.10"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/3527608982"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.10.77"},{"key":"e_1_2_3_27_2","first-page":"210","author":"Kremer C.","year":"2011","journal-title":"Synthesis"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1515\/HC.1997.3.6.493"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802691105"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.05.015"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867311320210004"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-011-9971-0"},{"key":"e_1_2_3_33_2","first-page":"113","volume":"9","author":"Job P.","year":"1928","journal-title":"Ann. Chim."},{"key":"e_1_2_3_34_2","unstructured":"Molecular modelling was performed by using the commercially available software package Spartan \u201910 from Wavefunction Inc. Irvine USA www.wavefun.com."},{"key":"e_1_2_3_35_2","unstructured":"Please note that adding an excess of zinc(II) to the mixture of capsaicin 1 5 Zn2+ and EDTA did not allow to reestablish the formation of the [Zn(5)(1)]2+complex. However one might be able to overcome this problem by just using zinc(II) ions as an effector because this might be much easier to remove from the [Zn(1)2]2+complex that we have observed. Although one might not be able to determine accurate binding constants for this systems it might still be very useful from a functional point of view for example for the extraction or transport of nonpolar substrates such as capsaicin especially because it can bind up to two guest molecules."}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.201403503","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201403503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T12:14:32Z","timestamp":1760271272000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.201403503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":38,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2014,7,14]]}},"alternative-id":["10.1002\/chem.201403503"],"URL":"https:\/\/doi.org\/10.1002\/chem.201403503","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,20]]}}}