{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:39:40Z","timestamp":1789810780031,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2014,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Positron emission tomography has emerged as the leading method for medical imaging with fluorine\u201018 as the most widely used radioactive isotope. Here we report a semi\u2010automated method for the preparation of valuable [<jats:sup>18<\/jats:sup>F]trifluoromethylcopper, as well as its use for the radiosynthesis of [<jats:sup>18<\/jats:sup>F]trifluoromethylarenes and heteroarenes. Mild conditions of [<jats:sup>18<\/jats:sup>F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [<jats:sup>18<\/jats:sup>F]trifluoromethylarenes and heteroarenes.<\/jats:p>","DOI":"10.1002\/chem.201403630","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T10:43:35Z","timestamp":1403606615000},"page":"9514-9518","source":"Crossref","is-referenced-by-count":73,"title":["[<sup>18<\/sup>F]CuCF<sub>3<\/sub>: A [<sup>18<\/sup>F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides"],"prefix":"10.1002","volume":"20","author":[{"given":"Pavel","family":"Ivashkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rald","family":"Lemonnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Cousin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Gr\u00e9goire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Labar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jubault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Pannecoucke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"e_1_2_3_1_2","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9226"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0782426"},{"key":"e_1_2_3_4_2","unstructured":"For selected reviews see:"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200800222"},{"key":"e_1_2_3_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800222"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.09.007"},{"key":"e_1_2_3_7_2","unstructured":"For recent electrophilic late\u2010stage [18F]fluorination methodologies see:"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201106785"},{"key":"e_1_2_3_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201106785"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201204687"},{"key":"e_1_2_3_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204687"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212625"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3084797"},{"key":"e_1_2_3_11_3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059187"},{"key":"e_1_2_3_12_2","unstructured":"\u00a0"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988589"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781444312096"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470281895"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580400101"},{"key":"e_1_2_3_17_2","unstructured":"\u00a0"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/c39860000924"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580281213"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0883-2889(90)90059-P"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580330805"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0969-8043(93)90025-6"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.11.033"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol4009377"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1756"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC01641F"},{"key":"e_1_2_3_27_2","unstructured":"\u00a0"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2081026"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201201613"},{"key":"e_1_2_3_29_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201613"},{"key":"e_1_2_3_30_2","unstructured":"\u00a0"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1139(00)81548-1"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1227859"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc37833k"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol070195g"},{"key":"e_1_2_3_35_2","unstructured":"Compound1free of CH2Cl2can be obtained as a white powder. 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