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A convenient strategy for creating magnetically encoded luminescent CdTe@SiO<jats:sub>2<\/jats:sub>@<jats:italic>n<\/jats:italic>\u2009Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> composite nanoparticles, by using a layer\u2010by\u2010layer self\u2010assembly approach based on electrostatic interactions, is described. Silica\u2010coated CdTe quantum dots (CdTe@SiO<jats:sub>2<\/jats:sub>) serve as core templates for the deposition of alternating layers of Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> magnetic nanoparticles and poly(dimethyldiallyl ammonium chloride), to construct CdTe@SiO<jats:sub>2<\/jats:sub>@<jats:italic>n<\/jats:italic>\u2009Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> (<jats:italic>n<\/jats:italic>=1, 2, 3, \u2026\ufe01) composite nanoparticles with a defined number (<jats:italic>n<\/jats:italic>) of Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> layers. Composite nanoparticles were characterized by zeta\u2010potential analysis, fluorescence spectroscopy, vibrating sample magnetometry, and transmission electron microscopy, which showed that the CdTe@SiO<jats:sub>2<\/jats:sub>@<jats:italic>n<\/jats:italic>\u2009Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> composite nanoparticles exhibited excellent luminescence properties coupled with well\u2010defined magnetic responses. To demonstrate the utility of these magnetically encoded nanoparticles for near\u2010simultaneous detection and separation of multiple components from complex samples, three different fluorescently labeled IgG proteins, as model targets, were identified and collected from a mixture by using the CdTe@SiO<jats:sub>2<\/jats:sub>@<jats:italic>n<\/jats:italic>\u2009Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> nanoparticles.<\/jats:p>","DOI":"10.1002\/chem.201403699","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T03:40:41Z","timestamp":1411702841000},"page":"14642-14649","source":"Crossref","is-referenced-by-count":18,"title":["Magnetically Encoded Luminescent Composite Nanoparticles through Layer\u2010by\u2010Layer 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