{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:01:41Z","timestamp":1779156101260,"version":"3.51.4"},"reference-count":83,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2014,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polystyrene\u2010supported (PS) diarylprolinol catalysts <jats:bold>1\u2009a<\/jats:bold> (Ar=phenyl) and <jats:bold>1\u2009b<\/jats:bold> (Ar=3,5\u2010bis(trifluoromethyl)phenyl) have been developed. Operating under site\u2010isolation conditions, PS\u2010<jats:bold>1\u2009a<\/jats:bold>\/<jats:bold>1\u2009b<\/jats:bold> worked compatibly with PS\u2010bound sulfonic acid catalyst <jats:bold>2<\/jats:bold> to promote deoligomerization of paraldehyde and subsequent cross\u2010aldol reactions of the resulting acetaldehyde in one pot, affording aldol products in high yields with excellent enantioselectivities. The effect of water on the performance of the catalytic system has been studied and its optimal amount (0.5\u2005equiv) has been determined. The dual catalytic system (<jats:bold>1<\/jats:bold>\/<jats:bold>2<\/jats:bold>) allows repeated recycling and reuse (10 cycles). The potential of this methodology is demonstrated by a two\u2010step synthesis of a phenoperidine analogue (68\u2009% overall yield; 98\u2009%\u2005<jats:italic>ee<\/jats:italic>) and by the preparation of highly enantioenriched 1,3\u2010diols <jats:bold>4<\/jats:bold> and 3\u2010methylamino\u20101\u2010arylpropanols <jats:bold>5<\/jats:bold>, key intermediates in the synthesis of a variety of druglike structures.<\/jats:p>","DOI":"10.1002\/chem.201404215","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T11:38:14Z","timestamp":1409225894000},"page":"13089-13093","source":"Crossref","is-referenced-by-count":29,"title":["Highly Enantioselective Cross\u2010Aldol Reactions of Acetaldehyde Mediated by a Dual Catalytic System Operating under Site Isolation"],"prefix":"10.1002","volume":"20","author":[{"given":"Xinyuan","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Rodr\u00edguez\u2010Escrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoulei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Sayalero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miquel 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