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The ligands form stable complexes with transition metal ions. Both ligands show high thermodynamic selectivity for divalent copper over nickel(II) and zinc(II)\u2014<jats:italic>K<\/jats:italic>(CuL) is larger than <jats:italic>K<\/jats:italic>(Ni\/ZnL) by about seven orders of magnitude. Complexation is significantly faster for the phosphonate ligand H<jats:sub>4<\/jats:sub><jats:bold>L2<\/jats:bold>, probably due to the stronger coordination ability of the more basic phosphonate groups, which efficiently bind the metal ion in an \u201cout\u2010of\u2010cage\u201d complex and thus accelerate its \u201cin\u2010cage\u201d binding. The rate of Cu<jats:sup>II<\/jats:sup> complexation by the phosphinate ligand H<jats:sub>2<\/jats:sub><jats:bold>L1<\/jats:bold> is comparable to that of cyclam itself and its derivatives with non\u2010coordinating substituents. Acid\u2010assisted decomplexation of the copper(II) complexes is relatively fast (<jats:italic>\u03c4<\/jats:italic><jats:sub>1\/2<\/jats:sub>=44 and 42\u2005s in 1\u2009<jats:sc>M<\/jats:sc> aq. HClO<jats:sub>4<\/jats:sub> at 25\u2009\u00b0C for H<jats:sub>2<\/jats:sub><jats:bold>L1<\/jats:bold> and H<jats:sub>4<\/jats:sub><jats:bold>L2<\/jats:bold>, respectively). This combination of properties is convenient for selective copper removal\/purification. Thus, the title ligands were employed in the preparation of ion\u2010selective resins for radiocopper(II) separation. Glycidyl methacrylate copolymer beads were modified with the ligands through a diazotisation reaction. The separation ability of the modified polymers was tested with cold copper(II) and non\u2010carrier\u2010added <jats:sup>64<\/jats:sup>Cu in the presence of a large excess of both nickel(II) and zinc(II). The experiments exhibited high overall separation efficiency leading to 60\u201370\u2009% recovery of radiocopper with high selectivity over the other metal ions, which were originally present in 900\u2010fold molar excess. The results showed that chelating resins with properly tuned selectivity of their complexing moieties can be employed for radiocopper separation.<\/jats:p>","DOI":"10.1002\/chem.201405777","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T16:28:11Z","timestamp":1422980891000},"page":"4671-4687","source":"Crossref","is-referenced-by-count":20,"title":["Bifunctional Cyclam\u2010Based Ligands with Phosphorus Acid Pendant Moieties for Radiocopper Separation: Thermodynamic and Kinetic Studies"],"prefix":"10.1002","volume":"21","author":[{"given":"Monika","family":"Pa\u00farov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Havl\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Posp\u00ed\u0161ilov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Vetr\u00edk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"C\u00edsa\u0159ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010J\u00fcrgen","family":"Pietzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrub\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kotek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,3]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(98)00169-6"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-8838(08)60025-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/B704360K"},{"key":"e_1_2_6_4_2","volume-title":"The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging","year":"2013"},{"key":"e_1_2_6_5_2","volume-title":"Topics in Current Chemistry, Vol.\u2005221","year":"2002"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-8838(05)57004-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/b510982p"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/b719704g"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr980451q"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr9804386"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b309961j"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc000070v"},{"key":"e_1_2_6_13_2","volume-title":"Handbook of Radiopharmaceuticals: Radiochemistry and Applications","author":"Welch M. 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