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During the photon\u2010to\u2010electricity conversion in PEC processes, electron\u2013hole (charge) separation competes with electron\u2013hole recombination, and the net effect essentially determines the performance of PEC biosensors. Herein, we propose a new approach for slowing down electron\u2013hole recombination to increase charge separation efficiency for PEC biosensor development. Through doping with Mn<jats:sup>2+<\/jats:sup>, a pair of d bands (<jats:sup>4<\/jats:sup>T<jats:sub>1<\/jats:sub> and <jats:sup>6<\/jats:sup>A<jats:sub>1<\/jats:sub>) is inserted between the conduction and valence bands of CdS QDs, which alters the electron\u2013hole separation and recombination dynamics, allowing the generation of long\u2010lived charge carriers with ms\u2010scale lifetime that decay about 10<jats:sup>4<\/jats:sup>\u201310<jats:sup>5<\/jats:sup>\u2010fold more slowly than in the case of undoped QDs. Photocurrent tests indicated that Mn<jats:sup>2+<\/jats:sup> doping resulted in an approximately 80\u2009% increase in photocurrent generation compared with undoped CdS QDs. For application, the Mn\u2010doped CdS QDs were coated on the surface of a glassy carbon electrode and functionalized with a cell surface carbohydrate\u2010specific ligand (3\u2010aminophenylboronic acid). In this way, a sensitive cytosensor for K562 leukemia cells was constructed. Moreover, the sugar\u2010specific binding property of 3\u2010aminophenylboronic acid allowed the electrode to serve as a switch for the capture and release of cells. This has been further explored with a view to developing a reusable PEC cytosensing platform.<\/jats:p>","DOI":"10.1002\/chem.201405798","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T06:48:11Z","timestamp":1423810091000},"page":"5129-5135","source":"Crossref","is-referenced-by-count":71,"title":["Long\u2010Lived Charge Carriers in Mn\u2010Doped CdS Quantum Dots for Photoelectrochemical Cytosensing"],"prefix":"10.1002","volume":"21","author":[{"given":"Peng","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Bing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiandeng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Juan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_5_1_2","unstructured":"\u00a0"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr500100j"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/am3028662"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.elecom.2013.10.035"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201201772"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00228H"},{"key":"e_1_2_5_7_2","unstructured":"\u00a0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc35643k"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00084a"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/C1CC16060E"},{"key":"e_1_2_5_11_2","unstructured":"\u00a0"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl4028507"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201100427"},{"key":"e_1_2_5_14_2","unstructured":"\u00a0"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja057040t"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac300127s"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2010.09.051"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac051926y"},{"key":"e_1_2_5_19_2","unstructured":"\u00a0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201001654"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac501406x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2009.08.027"},{"key":"e_1_2_5_23_2","unstructured":"\u00a0"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl500608w"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc34543a"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201102379"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2010.01.036"},{"key":"e_1_2_5_28_2","first-page":"145","volume":"9","author":"Becquerel A. 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