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To assess the extent of displacement at equilibrium, the stability constants of DTPA\u2010BMA<jats:sup>3\u2212<\/jats:sup> complexes of Gd<jats:sup>3+<\/jats:sup>, Ca<jats:sup>2+<\/jats:sup>, Zn<jats:sup>2+<\/jats:sup>, and Cu<jats:sup>2+<\/jats:sup> have been determined at 37\u2009\u00b0C in 0.15\u2009<jats:sc>M<\/jats:sc> NaCl. The order of these stability constants is as follows: GdL\u2248CuL&gt;ZnL\u226bCaL. Applying a simplified blood plasma model, the extent of dissociation of Omniscan (0.35\u2005m<jats:sc>M<\/jats:sc> [Gd(DTPA\u2010BMA)]) was found to be 17\u2009% by the formation of Gd(PO<jats:sub>4<\/jats:sub>), [Zn(DTPA\u2010BMA)]<jats:sup>\u2212<\/jats:sup> (2.4\u2009%), [Cu(DTPA\u2010BMA)]<jats:sup>\u2212<\/jats:sup> (0.2\u2009%), and [Ca(DTPA\u2010BMA)]<jats:sup>\u2212<\/jats:sup> (17.7\u2009%). By capillary electrophoresis, the formation of [Ca(DTPA\u2010BMA)]<jats:sup>\u2212<\/jats:sup> has been detected in human serum spiked with [Gd(DTPA\u2010BMA)] (2.0\u2005m<jats:sc>M<\/jats:sc>) at pH\u20057.4. Transmetallation reactions between [Gd(DTPA\u2010BMA)] and Cu<jats:sup>2+<\/jats:sup> at 37\u2009\u00b0C in the presence of citrate, phosphate, and bicarbonate ions occur by dissociation of the complex assisted by the endogenous ligands. At physiological concentrations of citrate, phosphate, and bicarbonate ions, the half\u2010life of dissociation of [Gd(DTPA\u2010BMA)] was calculated to be 9.3\u2005h at pH\u20057.4. Considering the rates of distribution and dissociation of [Gd(DTPA\u2010BMA)] in the extracellular space of the body, an open two\u2010compartment model has been developed, which allows prediction of the extent of dissociation of the Gd<jats:sup>III<\/jats:sup> complex in body fluids depending on the rate of elimination of the contrast agent.<\/jats:p>","DOI":"10.1002\/chem.201405967","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T06:47:54Z","timestamp":1423810074000},"page":"4789-4799","source":"Crossref","is-referenced-by-count":58,"title":["The Role of Equilibrium and Kinetic Properties in the Dissociation of Gd[DTPA\u2010bis(methylamide)] (Omniscan) at near to Physiological Conditions"],"prefix":"10.1002","volume":"21","author":[{"given":"Zsolt","family":"Baranyai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ern\u0151","family":"Br\u00fccher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Uggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Maiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Andr\u00e1si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"G\u00e1sp\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Z\u00e9k\u00e1ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Aime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr980440x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781118503652.ch4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8748-0"},{"key":"e_1_2_6_5_2","first-page":"167","volume":"16","author":"Weinmann H. 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