{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:51:57Z","timestamp":1791154317081,"version":"4.1.0"},"reference-count":96,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Basic Research Program of China","award":["2013CB834802"],"award-info":[{"award-number":["2013CB834802"]}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"crossref","award":["AoE\/P-03\/08"],"award-info":[{"award-number":["AoE\/P-03\/08"]}],"id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011053","name":"CAS-Croucher Funding Scheme for Joint Laboratories","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011053","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2015,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two classes of pincer\u2010type Pt<jats:sup>II<\/jats:sup> complexes containing tridentate N\u2010donor ligands (<jats:bold>1<\/jats:bold>\u2013<jats:bold>8<\/jats:bold>) or C\u2010deprotonated N^C^N ligands derived from 1,3\u2010di(2\u2010pyridyl)benzene (<jats:bold>10<\/jats:bold>\u2013<jats:bold>13<\/jats:bold>) and auxiliary N\u2010heterocyclic carbene (NHC) ligand were synthesized. [Pt(trpy)(NHC)]<jats:sup>2+<\/jats:sup> complexes <jats:bold>1<\/jats:bold>\u2013<jats:bold>5<\/jats:bold> display green phosphorescence in CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub> (<jats:italic>\u03a6<\/jats:italic>: 1.1\u20135.3\u2009%; <jats:italic>\u03c4<\/jats:italic>: 0.3\u20131.0\u2005\u03bcs) at room temperature. Moderate\u2010to\u2010intense emissions are observed for <jats:bold>1<\/jats:bold>\u2013<jats:bold>7<\/jats:bold> in glassy solutions at 77\u2005K and for <jats:bold>1<\/jats:bold>\u2013<jats:bold>6<\/jats:bold> in the solid state. The [Pt(N^C^N)(NHC)]<jats:sup>+<\/jats:sup> complexes <jats:bold>10<\/jats:bold>\u2013<jats:bold>13<\/jats:bold> display strong green phosphorescence with quantum yields up to 65\u2009% in CHCl<jats:sub>3<\/jats:sub>. The reactions of <jats:bold>1<\/jats:bold> with a wide variety of anions were examined in various solvents. The tridentate N\u2010donor ligand of <jats:bold>1<\/jats:bold> undergoes displacement reaction with CN<jats:sup>\u2212<\/jats:sup> in protic solvents. Similar displacement of the N^C^N ligand by CN<jats:sup>\u2212<\/jats:sup> has been observed for <jats:bold>10<\/jats:bold>, leading to a luminescence \u201cswitch\u2010off\u201d response. The water\u2010soluble <jats:bold>7<\/jats:bold> containing anthracenyl\u2010functionalized NHC ligand acts as a light \u201cswitch\u2010on\u201d sensor for the detection of CN<jats:sup>\u2212<\/jats:sup> ion with high selectivity. The in vitro cytotoxicity of the Pt<jats:sup>II<\/jats:sup> complexes towards HeLa cells has been evaluated. Complex <jats:bold>12<\/jats:bold> showed high cytotoxicity with IC<jats:sub>50<\/jats:sub> value of 0.46\u2005\u03bc<jats:sc>M<\/jats:sc>, whereas <jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold> and <jats:bold>6<\/jats:bold>\u2013<jats:bold>8<\/jats:bold> are less cytotoxic. The cellular localization of the strongly luminescent complex <jats:bold>12<\/jats:bold> traced by using emission microscopy revealed that it mainly localizes in the cytoplasmic structures rather than in the nucleus. This complex can induce mitochondria dysfunction and subsequent cell death.<\/jats:p>","DOI":"10.1002\/chem.201406453","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T16:10:16Z","timestamp":1427991016000},"page":"7441-7453","source":"Crossref","is-referenced-by-count":92,"title":["Pincer\u2010Type Platinum(II) Complexes Containing N\u2010Heterocyclic Carbene (NHC) Ligand: Structures, Photophysical and Anion\u2010Binding Properties, and Anticancer Activities"],"prefix":"10.1002","volume":"21","author":[{"given":"Kai","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Ming","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4]]},"reference":[{"key":"e_1_2_6_1_2","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(02)00041-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0781059"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.04.013"},{"key":"e_1_2_6_5_2","unstructured":"\u00a0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar100130j"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/a807914e"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja047955s"},{"key":"e_1_2_6_9_2","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/DT9930002933"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic00082a017"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic00122a015"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic961068b"},{"key":"e_1_2_6_14_2","unstructured":"\u00a0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/om010336x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic025580a"},{"key":"e_1_2_6_17_2","unstructured":"\u00a0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/om1007488"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2CC37135A"},{"key":"e_1_2_6_20_2","unstructured":"\u00a0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200802707"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201000167"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1sc00267h"},{"key":"e_1_2_6_24_2","unstructured":"\u00a0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja034891x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201201148"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/om4007054"},{"key":"e_1_2_6_28_2","unstructured":"\u00a0"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/b804019b"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1039\/b927099j"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic101632v"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc12943k"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/om200687w"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt32866j"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201001316"},{"key":"e_1_2_6_35_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201001316"},{"key":"e_1_2_6_36_2","unstructured":"\u00a0"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3sc21822h"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3048656"},{"key":"e_1_2_6_39_2","unstructured":"\u00a0"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201003606"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/om9008247"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc40953h"},{"key":"e_1_2_6_43_2","unstructured":"\u00a0"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.09.004"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/om400228s"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic990446k"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic035083"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200905678"},{"key":"e_1_2_6_49_2","unstructured":"\u00a0"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja037783j"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja203920w"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja406810a"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.12.053"},{"key":"e_1_2_6_54_2","unstructured":"\u00a0"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010202)40:3<486::AID-ANIE486>3.0.CO;2-P"},{"key":"e_1_2_6_55_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20010202)113:3<502::AID-ANGE502>3.0.CO;2-A"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar040071t"},{"key":"e_1_2_6_57_2","unstructured":"\u00a0"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1039\/B907368J"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4cs00008k"},{"key":"e_1_2_6_60_2","unstructured":"\u00a0"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(02)00258-8"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar050195l"},{"key":"e_1_2_6_63_2","unstructured":"\u00a0"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201300049"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja312313f"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2RA22205A"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc80006g"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201200008"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1039\/B510795D"},{"key":"e_1_2_6_70_2","unstructured":"\u00a0"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol902852g"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc14963f"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol2018856"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic301256g"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1039\/C1JM15072C"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt31244a"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2CC37243F"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200902741"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1309"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo035153u"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.19960021222"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1021\/om1001292"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570180436"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/j100678a001"},{"key":"e_1_2_6_85_2","unstructured":"G.\u2005M. Sheldrick SHEXS97. Programs for crystal structure analysis (Release 97\u20132). University of Goetingen Germany1997."},{"key":"e_1_2_6_86_2","unstructured":"G.\u2005M. Sheldrick SHEXL97. Programs for crystal structure analysis (Release 97\u20132). University of Goetingen Germany1997."},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.77.3865"},{"key":"e_1_2_6_88_2","unstructured":"\u00a0"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.444267"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00533485"},{"key":"e_1_2_6_91_2","unstructured":"\u00a0"},{"key":"e_1_2_6_92_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.452288"},{"key":"e_1_2_6_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01114537"},{"key":"e_1_2_6_94_2","unstructured":"Gaussian\u200509 Revision\u2005C.01 M.\u2005J. Frisch G.\u2005W. Trucks H.\u2005B. Schlegel G.\u2005E. Scuseria M.\u2005A. Robb J.\u2005R. Cheeseman G. Scalmani V. Barone B. Mennucci G.\u2005A. Petersson H. Nakatsuji M. Caricato X. Li H.\u2005P. Hratchian A.\u2005F. Izmaylov J. Bloino G. Zheng J.\u2005L. Sonnenberg M. Hada M. Ehara K. Toyota R. Fukuda J. Hasegawa M. Ishida T. Nakajima Y. Honda O. Kitao H. Nakai T. Vreven J.\u2005A. Montgomery \u2005Jr. J.\u2005E. Peralta F. Ogliaro M. Bearpark J.\u2005J. Heyd E. Brothers K.\u2005N. Kudin V.\u2005N. Staroverov R. Kobayashi J. Normand K. Raghavachari A. Rendell J.\u2005C. Burant S.\u2005S. Iyengar J. Tomasi M. Cossi N. Rega J.\u2005M. Millam M. Klene J.\u2005E. Knox J.\u2005B. Cross V. Bakken C. Adamo J. Jaramillo R. Gomperts R.\u2005E. Stratmann O. Yazyev A.\u2005J. Austin R. Cammi C. Pomelli J.\u2005W. Ochterski R.\u2005L. Martin K. Morokuma V.\u2005G. Zakrzewski G.\u2005A. Voth P. Salvador J.\u2005J. Dannenberg S. Dapprich A.\u2005D. Daniels O. Farkas J.\u2005B. Foresman J.\u2005V. Ortiz J. Cioslowski and D.\u2005J. Fox Gaussian Inc. Wallingford CT 2011."}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.201406453","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201406453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T18:23:31Z","timestamp":1760293411000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.201406453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":96,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2015,5,11]]}},"alternative-id":["10.1002\/chem.201406453"],"URL":"https:\/\/doi.org\/10.1002\/chem.201406453","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}