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Based on a less common central carbon\u2013carbon bond disconnection, this protocol complements traditional approaches that involve amines and various carbon electrophiles (epoxides, \u03b1\u2010halo ketones, \u03b2\u2010halohydrins). Medicinally relevant products can be prepared in a concise and efficient way from simple building blocks, as demonstrated in the synthesis of the antiasthma drug salbutamol. Upgrading the synthesis to an enantioselective variant is also feasible.<\/jats:p>","DOI":"10.1002\/chem.201500210","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T07:57:30Z","timestamp":1428911850000},"page":"7808-7813","source":"Crossref","is-referenced-by-count":16,"title":["One\u2010Pot Synthesis of N\u2010Substituted \u03b2\u2010Amino Alcohols from Aldehydes and Isocyanides"],"prefix":"10.1002","volume":"21","author":[{"given":"R\u0103zvan C.","family":"Cioc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan J. 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