{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:54:38Z","timestamp":1776304478191,"version":"3.50.1"},"reference-count":87,"publisher":"Wiley","issue":"27","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"MEXT","doi-asserted-by":"crossref","award":["26105727"],"award-info":[{"award-number":["26105727"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007428","name":"The Naito Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"crossref"}]},{"name":"JGC-S Scholarship Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2015,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A direct enantioselective vinylogous Mannich reaction of ketimines with \u03b3\u2010butenolide has been developed. Good yields and enantioselectivities were observed for the reaction of various ketimines by using a cinchona alkaloid amide\/Zn(OTf)<jats:sub>2<\/jats:sub> catalyst and Et<jats:sub>3<\/jats:sub>N. Both enantiomers of the products could be obtained by using pseudoenantiomeric chiral catalysts.<\/jats:p>","DOI":"10.1002\/chem.201500599","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T09:56:59Z","timestamp":1430819819000},"page":"9615-9618","source":"Crossref","is-referenced-by-count":46,"title":["Direct Enantioselective Vinylogous Mannich Reaction of Ketimines with \u03b3\u2010Butenolide by Using Cinchona Alkaloid Amide\/Zinc(II) Catalysts"],"prefix":"10.1002","volume":"21","author":[{"given":"Shuichi","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"e_1_2_4_1_2","unstructured":"\u00a0"},{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm001049i"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar950230w"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo0162890"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0296024"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(03)00597-4"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo801470u"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo901059n"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol2020384"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100304n"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303119"},{"key":"e_1_2_4_11_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201303119"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4ra04824e"},{"key":"e_1_2_4_13_2","unstructured":"For 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catalytic enantioselective direct Mannich reactions with ketimines 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reviews on cinchona alkaloid catalysts see:"},{"key":"e_1_2_4_53_2","volume-title":"Cinchona Alkaloids in Synthesis & Catalysis","year":"2009"},{"key":"e_1_2_4_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.201400030"},{"key":"e_1_2_4_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja044179f"},{"key":"e_1_2_4_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201003542"},{"key":"e_1_2_4_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200902896"},{"key":"e_1_2_4_58_2","unstructured":"ForN\u2010heteroarene\u2010carbonylated orN\u2010heteroarene\u2010sulfonylated cinchona alkaloid catalysts see:"},{"key":"e_1_2_4_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201100410"},{"key":"e_1_2_4_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja309963w"},{"key":"e_1_2_4_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201200367"},{"key":"e_1_2_4_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200800981"},{"key":"e_1_2_4_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200900944"},{"key":"e_1_2_4_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201000214"},{"key":"e_1_2_4_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201404629"},{"key":"e_1_2_4_65_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201404629"},{"key":"e_1_2_4_66_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol503309s"},{"key":"e_1_2_4_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201406270"},{"key":"e_1_2_4_68_2","unstructured":"Recently we reported the reaction of some nucleophiles with various ketimines see:"},{"key":"e_1_2_4_69_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja908940e"},{"key":"e_1_2_4_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201300685"},{"key":"e_1_2_4_71_2","unstructured":"We also examined the reaction with various Lewis acids such as Cu(NTf2)2 ZnBr2 Zn(OAc)2 Zn(OTf)2 Zn(NTf2)2 and Ni(OTf)2; however the yield or enantioselectivity was lower than that for the reaction using Zn(OTf)2(see the Supporting Information)."},{"key":"e_1_2_4_72_2","unstructured":"Gaussian\u200509 Revision\u2005A.02 M.\u2005J. Frisch G.\u2005W. Trucks H.\u2005B. Schlegel G.\u2005E. Scuseria M.\u2005A. Robb J.\u2005R. Cheeseman G. Scalmani V. Barone B. Mennucci G.\u2005A. Petersson H. Nakatsuji M. Caricato X. Li H.\u2005P. Hratchian A.\u2005F. Izmaylov J. Bloino G. Zheng J.\u2005L. Sonnenberg M. Hada M. Ehara K. Toyota R. Fukuda J. Hasegawa M. Ishida T. Nakajima Y. Honda O. Kitao H. Nakai T. Vreven J.\u2005A. Montgomery \u2005Jr. J.\u2005E. Peralta F. Ogliaro M. Bearpark J.\u2005J. Heyd E. Brothers K.\u2005N. Kudin V.\u2005N. Staroverov R. Kobayashi J. Normand K. Raghavachari A. Rendell J.\u2005C. Burant S.\u2005S. Iyengar J. Tomasi M. Cossi N. Rega J.\u2005M. Millam M. Klene J.\u2005E. Knox J.\u2005B. Cross V. Bakken C. Adamo J. Jaramillo R. Gomperts R.\u2005E. Stratmann O. Yazyev A.\u2005J. Austin R. Cammi C. Pomelli J.\u2005W. Ochterski R.\u2005L. Martin K. Morokuma V.\u2005G. Zakrzewski G.\u2005A. Voth P. Salvador J.\u2005J. Dannenberg S. Dapprich A.\u2005D. Daniels O. Farkas J.\u2005B. Foresman J.\u2005V. Ortiz J. Cioslowski D.\u2005J. Fox Gaussian Inc. Wallingford CT 2009."},{"key":"e_1_2_4_73_2","unstructured":"For B3LYP see:"},{"key":"e_1_2_4_74_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.464913"},{"key":"e_1_2_4_75_2","volume-title":"Modern Theoretical Chemistry, Vol.\u20053","author":"Dunning T. 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