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This cross\u2010coupling is triggered by radical trifluoromethylation of alkenes, thereby achieving highly selective remote difunctionalization of alkenes and \u03b1\u2010position of the carbonyl group for facile access to trifluoromethyl \u03b1\u2010halo\u2010 and \u03b1\u2010cyanocarbonyl compounds. The reaction exhibits a broad substrate scope with excellent functionality tolerance and many different types of nucleophiles; further synthetic applicability of the obtained compounds proved to be suitable, thus showing great potential for synthetic utility.<\/jats:p>","DOI":"10.1002\/chem.201500629","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T18:27:50Z","timestamp":1426184870000},"page":"6718-6722","source":"Crossref","is-referenced-by-count":39,"title":["Trifluoromethylation\u2010Initiated Remote Cross\u2010Coupling of Carbonyl Compounds to Form Carbon\u2013Heteroatom\/Carbon Bonds"],"prefix":"10.1002","volume":"21","author":[{"given":"Lin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Cai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"e_1_2_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527613267"},{"key":"e_1_2_3_2_2","unstructured":"For selected reviews on the polarity inversion approach see:"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471264180.or062.01"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-57565-0_76"},{"key":"e_1_2_3_5_2","first-page":"517","author":"Merritt E. 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