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Excellent inhibitory effects were observed with these nanoparticles, with <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub> values in the low nanomolar range (6.2\u20130.67\u2005n<jats:sc>M<\/jats:sc>) against all tested isozymes. A significant multivalency effect was seen for the inhibition of the monomeric enzymes hCA\u2005I and II compared to the dimeric hCA\u2005IX and hCA\u2005XII isoforms, where no multivalent effect was observed, suggesting that the multivalent binding is occurring through enzyme clustering.<\/jats:p>","DOI":"10.1002\/chem.201501037","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T11:53:13Z","timestamp":1431431593000},"page":"10306-10309","source":"Crossref","is-referenced-by-count":31,"title":["Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic 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