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The compounds were characterized by elemental analysis, IR spectroscopy, electrospray ionization (ESI) mass spectrometry, while <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, and <jats:bold>5<\/jats:bold> were in addition analyzed by X\u2010ray crystallography, <jats:bold>1<\/jats:bold> by Ru K\u2010edge XAS and <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> by <jats:sup>13<\/jats:sup>C\u2005NMR spectroscopy. X\u2010ray diffraction showed that in <jats:bold>2<\/jats:bold> and <jats:bold>5<\/jats:bold> four complex anions [RuCl<jats:sub>3<\/jats:sub>(ox)(NO)]<jats:sup>2\u2212<\/jats:sup> are coordinated to Y<jats:sup>III<\/jats:sup> and Dy<jats:sup>III<\/jats:sup>, respectively, with formation of [Ln{RuCl<jats:sub>3<\/jats:sub>(\u03bc\u2010ox)(NO)}<jats:sub>4<\/jats:sub>]<jats:sup>5\u2212<\/jats:sup> (Ln=Y, Dy). While Y<jats:sup>III<\/jats:sup> is eight\u2010coordinate in <jats:bold>2<\/jats:bold>, Dy<jats:sup>III<\/jats:sup> is nine\u2010coordinate in <jats:bold>5<\/jats:bold>, with an additional coordination of an EtOH molecule. The negative charge is counterbalanced by five <jats:italic>n<\/jats:italic>Bu<jats:sub>4<\/jats:sub>N<jats:sup>+<\/jats:sup> ions present in the crystal structure. The stability of complexes <jats:bold>2<\/jats:bold> and <jats:bold>5<\/jats:bold> in aqueous medium was monitored by UV\/Vis spectroscopy. The antiproliferative activity of ruthenium\u2010lanthanide complexes <jats:bold>2<\/jats:bold>\u2013<jats:bold>5<\/jats:bold> were assayed in two human cancer cell lines (HeLa and A549) and in a noncancerous cell line (MRC\u20105) and compared with those obtained for the previously reported Os(NO)\u2010Ln (5d\u20134f) analogues (<jats:italic>n<\/jats:italic>Bu<jats:sub>4<\/jats:sub>N)<jats:sub>5<\/jats:sub>[Ln{OsCl<jats:sub>3<\/jats:sub>(ox)(NO)}<jats:sub>4<\/jats:sub>] (Ln=Y (<jats:bold>6<\/jats:bold>), Gd (<jats:bold>7<\/jats:bold>), Tb (<jats:bold>8<\/jats:bold>), Dy (<jats:bold>9<\/jats:bold>)). Complexes <jats:bold>2<\/jats:bold>\u2013<jats:bold>5<\/jats:bold> were found to be slightly more active than <jats:bold>1<\/jats:bold> in inhibiting the proliferation of HeLa and A549 cells, and significantly more cytotoxic than 5d\u20134f metal complexes <jats:bold>6<\/jats:bold>\u2013<jats:bold>9<\/jats:bold> in terms of IC<jats:sub>50<\/jats:sub> values. The highest antiproliferative activity with IC<jats:sub>50<\/jats:sub> values of 20.0 and 22.4\u2005\u03bc<jats:sc>M<\/jats:sc> was found for <jats:bold>4<\/jats:bold> in HeLa and A549 cell lines, respectively. These cytotoxicity results are in accord with the presented ICP\u2010MS data, indicating five\u2010 to eightfold greater accumulation of ruthenium versus osmium in human A549 cancer cells.<\/jats:p>","DOI":"10.1002\/chem.201502026","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T21:40:05Z","timestamp":1439242805000},"page":"13703-13713","source":"Crossref","is-referenced-by-count":16,"title":["Heteropentanuclear Oxalato\u2010Bridged <i>n<\/i>d\u20134f (<i>n<\/i>=4, 5) Metal Complexes with NO Ligand: Synthesis, Crystal Structures, Aqueous Stability and Antiproliferative Activity"],"prefix":"10.1002","volume":"21","author":[{"given":"Paul\u2010Steffen","family":"Kuhn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatolie","family":"Gavriluta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina K.","family":"Jovanovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Filipovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred A.","family":"Hummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel E.","family":"B\u00fcchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana P.","family":"Doj\u010dinovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel M.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Rompel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sini\u0161a","family":"Radulovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Bernard","family":"Tommasino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Luneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir B.","family":"Arion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,10]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic400555k"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/zaac.201300054"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic4004824"},{"key":"e_1_2_6_4_2","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","unstructured":"F. 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