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The biological relationship between H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    S remains largely unknown in redox biology. In this study, we rationally designed and synthesized single\u2010 and dual\u2010response fluorescent probes for detecting both H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    S in living cells. The dual\u2010response probe was shown to be capable of mono\u2010 and dual\u2010detection of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    S selectively and sensitively. Detailed bioimaging studies based on the probes revealed that both exogenous and endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    could induce H\n                    <jats:sub>2<\/jats:sub>\n                    S biogenesis in living cells. By using gene\u2010knockdown techniques with bioimaging, the H\n                    <jats:sub>2<\/jats:sub>\n                    S biogenesis was found to be majorly cystathionine \u03b2\u2010synthase (CBS)\u2010dependent. Our finding shows the first direct evidence on the biological communication between H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    (ROS) and H\n                    <jats:sub>2<\/jats:sub>\n                    S (RSS) in vivo.\n                  <\/jats:p>","DOI":"10.1002\/chem.201502832","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T06:16:53Z","timestamp":1441347413000},"page":"15167-15172","source":"Crossref","is-referenced-by-count":53,"title":["A Dual\u2010Response Fluorescent Probe Reveals the H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    \u2010Induced H\n                    <sub>2<\/sub>\n                    S Biogenesis through a Cystathionine \u03b2\u2010Synthase 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