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Accumulating evidence indicates that miRNAs are aberrantly expressed in a variety of human cancers and that the inhibition of these oncogenic miRNAs could find application in the therapy of different types of cancer. Herein, we describe the synthesis and biological evaluation of new small\u2010molecule drugs that target oncogenic miRNAs production. In particular, we chose to target two miRNAs (i.e., miRNA\u2010372 and \u2010373) implicated in various types of cancer, such as gastric cancer. Their precursors (pre\u2010miRNAs) are overexpressed in cancer cells and lead to mature miRNAs after cleavage of their stem\u2010loop structure by the enzyme Dicer in the cytoplasm. Some of the newly synthesized conjugates can inhibit Dicer processing of the targeted pre\u2010miRNAs in vitro with increased efficacy relative to our previous results (D.D. Vo et\u2005al., <jats:italic>ACS Chem. Biol<\/jats:italic>. <jats:bold>2014<\/jats:bold>, <jats:italic>9<\/jats:italic>, 711\u2013721) and, more importantly, to inhibit proliferations of adenocarcinoma gastric cancer (AGS) cells overexpressing these miRNAs, thus representing promising leads for future drug development.<\/jats:p>","DOI":"10.1002\/chem.201505094","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T07:42:53Z","timestamp":1456818173000},"page":"5350-5362","source":"Crossref","is-referenced-by-count":67,"title":["Oncogenic MicroRNAs Biogenesis as a Drug Target: Structure\u2013Activity Relationship Studies on New Aminoglycoside Conjugates"],"prefix":"10.1002","volume":"22","author":[{"given":"Duc Duy","family":"Vo","sequence":"first","affiliation":[{"name":"University of Nice Sophia Antipolis Institute of Chemistry of Nice, UMR7272 CNRS, Parc Valrose  06100 Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Phuong 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