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A well\u2010studied gel\u2010inducing supramolecular synthon, namely primary ammonium monocarboxylate (PAM), has been exploited to generate a series of PAM salts by reacting ibuprofen with various primary amines. Remarkably, all of the salts (<jats:bold>S1<\/jats:bold>\u2013<jats:bold>S7<\/jats:bold>) thus synthesized proved to be good to moderate gelators of various polar and nonpolar solvents. Single\u2010crystal and powder X\u2010ray diffraction studies established the existence of the PAM synthons in the gel network, confirming the efficacy of the supramolecular synthon approach employed. Most importantly, the majority of the salts (<jats:bold>S2<\/jats:bold>, <jats:bold>S3<\/jats:bold>, <jats:bold>S6<\/jats:bold>, and <jats:bold>S7<\/jats:bold>) were capable of gelling methyl salicylate (MS), an important ingredient found in many commercial topical gels. In vitro experiments (MTT and PGE<jats:sub>2<\/jats:sub> assays) revealed that all of the salts (except <jats:bold>S3<\/jats:bold> and <jats:bold>S7<\/jats:bold>) were biocompatible (up to 0.5\u2005m<jats:sc>m<\/jats:sc> concentration), and the most suited one, <jats:bold>S6<\/jats:bold>, displayed anti\u2010inflammatory ability as good as that of the parent drug ibuprofen. A topical gel of <jats:bold>S6<\/jats:bold> with methyl salicylate and menthol was found to be suitable for delivering the gelator drug in a self\u2010delivery fashion in treating skin inflammation in mice. Histological studies, including immunohistology, were performed to further probe the role of the gelator drug <jats:bold>S6<\/jats:bold> in treating inflammation. Cell imaging studies supported cellular uptake of the gelator drug in such biomedical application.<\/jats:p>","DOI":"10.1002\/chem.201600105","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T20:22:29Z","timestamp":1464207749000},"page":"9257-9266","source":"Crossref","is-referenced-by-count":31,"title":["Supramolecular Gels by Design: Towards the Development of Topical Gels for Self\u2010Delivery Application"],"prefix":"10.1002","volume":"22","author":[{"given":"Rumana","family":"Parveen","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Indian Association for the Cultivation of Science  2A &amp; 2B Raja S.C. 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