{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:26:04Z","timestamp":1760898364486,"version":"build-2065373602"},"reference-count":55,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["25860032"],"award-info":[{"award-number":["25860032"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006089","name":"Tojuro Iijima Foundation for Food Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006089","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2016,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have developed a novel naphthalimide\u2010based Cd<jats:sup>2+<\/jats:sup> fluorescent probe (<jats:bold>1<\/jats:bold>), featuring almost no background response, high sensitivity and selectivity toward Cd<jats:sup>2+<\/jats:sup> through its high association constant [<jats:italic>K<\/jats:italic>=(2.10\u00b10.423)\u00d710<jats:sup>6<\/jats:sup>], and a practical working pH range. Membrane\u2010permeability was conferred on <jats:bold>1<\/jats:bold> by replacing the imide and amide substituents with <jats:italic>n<\/jats:italic>\u2010butyl groups, and hence the derivative (<jats:bold>4<\/jats:bold>) has found practical utility on fluorescent imaging of Cd<jats:sup>2+<\/jats:sup> in HeLa cells. Comparison of fluorescent properties between various compounds derived from <jats:bold>1<\/jats:bold> has demonstrated that the carbamoylmethyl groups in <jats:bold>1<\/jats:bold> function not only as Cd<jats:sup>2+<\/jats:sup> chelators but also as promoters for photoinduced electron transfer (PET) by lowering the basicity of the two tertiary amino groups. As a result, <jats:bold>1<\/jats:bold> and <jats:bold>4<\/jats:bold> exhibited highly practical performance as Cd<jats:sup>2+<\/jats:sup> probes under neutral conditions.<\/jats:p>","DOI":"10.1002\/chem.201600556","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T11:03:40Z","timestamp":1463051020000},"page":"8579-8585","source":"Crossref","is-referenced-by-count":18,"title":["A Naphthalimide\u2010Based Cd<sup>2+<\/sup> Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET\u2010Promoters under Neutral Conditions"],"prefix":"10.1002","volume":"22","author":[{"given":"Koji","family":"Tsukamoto","sequence":"first","affiliation":[{"name":"School of Pharmacy Hyogo University of Health Sciences  1-3-6 Minatojima, Chuo-ku, Kobe Hyogo 650-8530 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Shimabukuro","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hyogo University of Health Sciences  1-3-6 Minatojima, Chuo-ku, Kobe Hyogo 650-8530 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hyogo University of Health Sciences  1-3-6 Minatojima, Chuo-ku, Kobe Hyogo 650-8530 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatsuo","family":"Maeda","sequence":"additional","affiliation":[{"name":"School of Pharmacy Hyogo University of Health Sciences  1-3-6 Minatojima, Chuo-ku, Kobe Hyogo 650-8530 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00305-6"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.09.007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.10.013"},{"key":"e_1_2_6_5_1","first-page":"143","volume":"54","author":"Grant C. 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