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The combination of proline and a urea Br\u00f8nsted base cocatalyst is key for the reactions to proceed under very mild conditions (3\u201310\u2005mol\u2009% catalyst loading, dichloromethane as solvent, \u221220\u2009\u00b0C, 1.2\u2005molar equivalents of aldehyde) and with virtually total stereocontrol (<jats:italic>syn<\/jats:italic>\/<jats:italic>anti<\/jats:italic> ratio up to 99:1; <jats:italic>ee<\/jats:italic> up to 99\u2009%). Some possibilities of further chemical elaboration of adducts are also briefly illustrated.<\/jats:p>","DOI":"10.1002\/chem.201600635","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T21:14:06Z","timestamp":1458335646000},"page":"7229-7237","source":"Crossref","is-referenced-by-count":24,"title":["Development of a s<i>yn<\/i>\u2010Selective Mannich Reaction of Aldehydes with Propargylic Imines by Dual Catalysis: Asymmetric Synthesis of Functionalized Propargylic Amines"],"prefix":"10.1002","volume":"22","author":[{"given":"Irati","family":"Lapuerta","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I Universidad del Pa\u00eds Vasco UPV\/EHU  Manuel Lardizabal 3 20018 San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Vera","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I Universidad del Pa\u00eds Vasco UPV\/EHU  Manuel Lardizabal 3 20018 San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-0136","authenticated-orcid":false,"given":"Mikel","family":"Oiarbide","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I Universidad del Pa\u00eds Vasco UPV\/EHU  Manuel Lardizabal 3 20018 San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-2799","authenticated-orcid":false,"given":"Claudio","family":"Palomo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica I Universidad del Pa\u00eds Vasco UPV\/EHU  Manuel Lardizabal 3 20018 San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"e_1_2_6_1_1","volume-title":"Chiral Amine Synthesis: Methods, Developments and Applications","year":"2010"},{"key":"e_1_2_6_2_1","unstructured":"\u00a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm000023o"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00098a017"},{"key":"e_1_2_6_5_1","unstructured":"For selected examples see:"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0608545"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200353583"},{"key":"e_1_2_6_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200353583"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00093a002"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0001121"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00276a001"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00391a073"},{"key":"e_1_2_6_12_1","unstructured":"Reviews:"},{"key":"e_1_2_6_13_2","first-page":"43","volume":"44","author":"Yoo W. 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