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Such structurally diverse lesions are substrates for the nucleotide excision repair (NER). It is thought that the NER machinery recognises and verifies distorted DNA conformations, also involving the xeroderma pigmentosum group\u2005A and C proteins (XPA, XPC) that act as a scaffold between the DNA substrate and several other NER proteins. Here we present the synthesis of DNA molecules containing the polycyclic, aromatic amine C8\u2010guanine lesions acetylaminophenyl, acetylaminonaphthyl, acetylaminoanthryl, and acetylaminopyrenyl, as well as their crystal structures in complex with the yeast XPA homologue Rad14. This work further substantiates the indirect lesion\u2010detection mechanism employed by the NER system that recognises destabilised and deformable DNA structures.<\/jats:p>","DOI":"10.1002\/chem.201602438","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T19:24:42Z","timestamp":1464204282000},"page":"10782-10785","source":"Crossref","is-referenced-by-count":10,"title":["Structural Basis for Bulky\u2010Adduct DNA\u2010Lesion Recognition by the Nucleotide Excision Repair Protein Rad14"],"prefix":"10.1002","volume":"22","author":[{"given":"Nina","family":"Simon","sequence":"first","affiliation":[{"name":"Center for Integrated Protein Science Munich CIPSM Department of Chemistry Ludwig-Maximilians Universit\u00e4t M\u00fcnchen  Butenandtstrasse 13 81377 M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Ebert","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science Munich CIPSM Department of Chemistry Ludwig-Maximilians Universit\u00e4t M\u00fcnchen  Butenandtstrasse 13 81377 M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Schneider","sequence":"additional","affiliation":[{"name":"Center for Integrated Protein Science Munich CIPSM Department of Chemistry Technische Universit\u00e4t M\u00fcnchen  Lichtenbergstrasse 4 85748 Garching Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","first-page":"33","volume":"54","author":"Berneburg 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