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It consists of a thermo\u2010responsive poly(<jats:italic>N<\/jats:italic>\u2010isopropylacrylamide), also known as <jats:italic>p<\/jats:italic>NiPAM\u2010COOH, labeled with nitroxide radicals. The polymer powder is impregnated with an arbitrary solution of interest and frozen as is. Dissolution is followed by a simple filtration, leading to hyperpolarized solutions free from any contaminants. We demonstrated the use of FLAP to hyperpolarize partially deuterated water up to <jats:italic>P<\/jats:italic>(<jats:sup>1<\/jats:sup>H)=6\u2009% with a long relaxation <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> &gt;36\u2005s characteristic of high purity. Water hyperpolarization can be transferred to drugs, metabolites, or proteins that are waiting in an NMR spectrometer, either by exchange of labile protons or through intermolecular Overhauser effects. We also show that FLAPs are suitable polarizing agents for <jats:sup>13<\/jats:sup>C\u2010labeled metabolites such as pyruvate, acetate, and alanine.<\/jats:p>","DOI":"10.1002\/chem.201602506","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T03:26:50Z","timestamp":1471836410000},"page":"14696-14700","source":"Crossref","is-referenced-by-count":47,"title":["Filterable Agents for Hyperpolarization of Water, Metabolites, and Proteins"],"prefix":"10.1002","volume":"22","author":[{"given":"Basile","family":"Vuichoud","sequence":"first","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Bornet","sequence":"additional","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  1015 Lausanne 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