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The Dox\u2010loaded, Pluronic F108\u2010coated system (Dox@F108\u2010mNPs) was stable at room temperature and physiological pH and released its Dox cargo slowly under acidic conditions or in a sudden burst with magnetic heating. No significant toxicity was observed in vitro when Dox@F108\u2010mNPs were incubated with noncancerous cells, a result consistent with the minimal internalization of the particles that occurs with normal cells. On the other hand, the drug\u2010loaded particles significantly reduced the viability of cervical cancer cells (HeLa, IC<jats:sub>50<\/jats:sub>=0.70\u2005\u03bc<jats:sc>m<\/jats:sc>), wild\u2010type ovarian cancer cells (A2780, IC<jats:sub>50<\/jats:sub>=0.50\u2005\u03bc<jats:sc>m<\/jats:sc>) and Dox\u2010resistant ovarian cancer cells (A2780\/AD, IC<jats:sub>50<\/jats:sub>=0.53\u2005\u03bc<jats:sc>m<\/jats:sc>). In addition, the treatment of HeLa cells with both Dox@F108\u2010mNPs and subsequent alternating magnetic\u2010field\u2010induced hyperthermia was significantly more effective at reducing cell viability than either Dox or Dox@F108\u2010mNP treatment alone. Thus, Dox@F108\u2010mNPs constitute a novel soft\/hard hybrid nanocarrier system that is highly stable under physiological conditions, temperature\u2010responsive, and has chemo\u2010 and thermotherapeutic modes of action.<\/jats:p>","DOI":"10.1002\/chem.201602956","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T01:54:00Z","timestamp":1476410040000},"page":"17020-17028","source":"Crossref","is-referenced-by-count":40,"title":["Mesoporous \u03b3\u2010Iron Oxide Nanoparticles for Magnetically Triggered Release of Doxorubicin and Hyperthermia Treatment"],"prefix":"10.1002","volume":"22","author":[{"given":"Farah","family":"Benyettou","sequence":"first","affiliation":[{"name":"New York University  Abu Dhabi United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaen Alonso","family":"Ocadiz\u2005Flores","sequence":"additional","affiliation":[{"name":"New York University  Abu Dhabi United Arab 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