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This report particularly focuses on the challenging preparation of the arginine containing thiazole fragment, including the development of a robust, high yielding procedure that avoids the use of sulfurating agents. Extensive studies on the design of a coherent protecting group strategy and the establishment of a step\u2010efficient dicyclization\/oxidation approach allowed high levels of convergence for the construction of the oxazole fragments. This has led to a unified, highly convergent synthesis for both plantazolicin\u2005A and B.<\/jats:p>","DOI":"10.1002\/chem.201603157","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T07:54:18Z","timestamp":1473753258000},"page":"15902-15912","source":"Crossref","is-referenced-by-count":11,"title":["The Total Synthesis of the Bioactive Natural Product Plantazolicin\u2005A and Its Biosynthetic Precursor Plantazolicin\u2005B"],"prefix":"10.1002","volume":"22","author":[{"given":"Sabine","family":"Fenner","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield road CB21EW Cambridge UK"},{"name":"GlaxoSmithKline  Gunnels Wood Rd SG12NY Stevenage UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-9831","authenticated-orcid":false,"given":"Zoe E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield road CB21EW Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-0042","authenticated-orcid":false,"given":"Steven V.","family":"Ley","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cambridge  Lensfield road CB21EW Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,13]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164586"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"e_1_2_6_3_1","unstructured":"\u00a0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306101110"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc45898a"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol402444a"},{"key":"e_1_2_6_7_1","unstructured":"\u00a0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol200809m"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00784-10"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.000858"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507062"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201507062"},{"key":"e_1_2_6_12_1","unstructured":"\u00a0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00115"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.3.182"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb200339d"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb501042a"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201410063"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201410063"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201302266"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201302266"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol005777b"},{"key":"e_1_2_6_20_1","unstructured":"\u00a0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)77147-4"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/00397919008053164"},{"key":"e_1_2_6_23_2","first-page":"3535","author":"Merritt E. 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