{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:03:31Z","timestamp":1790247811008,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2017,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aggregates of amyloidogenic peptides are involved in the pathogenesis of several degenerative disorders. Herein, an iridium(III) complex,\n                    <jats:bold>Ir\u20101<\/jats:bold>\n                    , is reported as a chemical tool for oxidizing amyloidogenic peptides upon photoactivation and subsequently modulating their aggregation pathways.\n                    <jats:bold>Ir\u20101<\/jats:bold>\n                    was rationally designed based on multiple characteristics, including 1)\u2005photoproperties leading to excitation by low\u2010energy radiation; 2)\u2005generation of reactive oxygen species responsible for peptide oxidation upon photoactivation under mild conditions; and 3)\u2005relatively easy incorporation of a ligand on the Ir\n                    <jats:sup>III<\/jats:sup>\n                    center for specific interactions with amyloidogenic peptides. Biochemical and biophysical investigations illuminate that the oxidation of representative amyloidogenic peptides (i.e., amyloid\u2010\u03b2, \u03b1\u2010synuclein, and human islet amyloid polypeptide) is promoted by light\u2010activated\n                    <jats:bold>Ir\u20101<\/jats:bold>\n                    , which alters the conformations and aggregation pathways of the peptides. Additionally, their potential oxidation sites are identified as methionine, histidine, or tyrosine residues. Overall, our studies on\n                    <jats:bold>Ir\u20101<\/jats:bold>\n                    demonstrate the feasibility of devising metal complexes as chemical tools suitable for elucidating the nature of amyloidogenic peptides at the molecular level, as well as controlling their aggregation.\n                  <\/jats:p>","DOI":"10.1002\/chem.201604751","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T14:10:44Z","timestamp":1479305444000},"page":"1645-1653","source":"Crossref","is-referenced-by-count":45,"title":["An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation"],"prefix":"10.1002","volume":"23","author":[{"given":"Juhye","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Jung C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Seung","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuck Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Life Sciences UNIST  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong\u2010Gyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J.","family":"Korshavn","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Michigan  Ann Arbor MI 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Tak","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeheung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Emerging Materials Science Daegu Gyeongbuk Institute of Science and Technology (DGIST)  Daegu 42988 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayyalusamy","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Michigan  Ann Arbor MI 48109 USA"},{"name":"Biophysics University of Michigan  Ann Arbor MI 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Woo","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Hyuk","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-4996","authenticated-orcid":false,"given":"Mi Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6448"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar500152x"},{"key":"e_1_2_6_4_2","first-page":"879","volume":"152","author":"Baba M.","year":"1998","journal-title":"Am. 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