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The probe's unique sensing mechanism relies on the selective reduction of azide to amine by sulfide, followed by intramolecular cyclization to form a quinolinone. The quinolinone is a sensitizer that absorbs near\u2010UV light and transfers excitation energy to coordinated Tb<jats:sup>III<\/jats:sup> or Eu<jats:sup>III<\/jats:sup> ions to trigger a strong \u201cturn\u2010on\u201d luminescence response with ms\u2010scale lifetimes characteristic of lanthanide complexes. Using this probe, we developed a robust, high throughput screening (HTS) assay for detecting H<jats:sub>2<\/jats:sub>S generated by cystathionine \u03b3\u2010lyase (CSE), one of the main producers of H<jats:sub>2<\/jats:sub>S in mammalian cells. In a 240\u2010compound screen to identify potential CSE inhibitors, the Eu<jats:sup>III<\/jats:sup> analogue of the sensor showed a low false\u2010positive rate and high Z\u2032\u2010factor (&gt;0.7).<\/jats:p>","DOI":"10.1002\/chem.201604786","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T18:05:29Z","timestamp":1476381929000},"page":"752-756","source":"Crossref","is-referenced-by-count":20,"title":["Time\u2010Gated Detection of Cystathionine \u03b3\u2010Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor"],"prefix":"10.1002","volume":"23","author":[{"given":"Yao","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Illinois at Chicago  845 W. Taylor Street, MC 111 Chicago Illinois 60607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Illinois at Chicago  845 W. Taylor Street, MC 111 Chicago Illinois 60607 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy UICentre for Drug Discovery University of Illinois Cancer Center University of Illinois at Chicago  Chicago Illinois 60612 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul D.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy UICentre for Drug Discovery University of Illinois Cancer Center University of Illinois at Chicago  Chicago Illinois 60612 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiira","family":"Ratia","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy UICentre for Drug Discovery University of Illinois Cancer Center University of Illinois at Chicago  Chicago Illinois 60612 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory R. 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