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A facile and versatile approach for H<jats:sub>2<\/jats:sub>S production initiated by light irradiation and controlled by reaction with an amine or an amino acid was developed. The donor was synthesized in a one\u2010pot reaction, and simple crystallization led to a yield of approximately 90\u2009%. The synthetic strategy is scalable and versatile, and the H<jats:sub>2<\/jats:sub>S donors can be expressed ina number of different molecular and macromolecular forms, including crystalline small\u2010molecule compounds, water\u2010soluble polymers, polystyrene films, and hydrogels. The H<jats:sub>2<\/jats:sub>S donors based on polystyrene film and hydrogel were used as cell\u2010culture scaffolds. The H<jats:sub>2<\/jats:sub>S donor based on water\u2010soluble polymer was applied in photocontrolled inhibition of P\u2010selectin expression on human platelets and subsequent regulation of platelet aggregation. This study provides the simplest controllable H<jats:sub>2<\/jats:sub>S source to study its biological functions. The developed materials are also new therapeutic platforms to deliver H<jats:sub>2<\/jats:sub>S, as there is no accumulation of toxic byproducts, and the donor materials from polystyrene films and hydrogels can be readily removed after releasing H<jats:sub>2<\/jats:sub>S.<\/jats:p>","DOI":"10.1002\/chem.201701206","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T08:58:47Z","timestamp":1494406727000},"page":"11294-11300","source":"Crossref","is-referenced-by-count":65,"title":["Triggered and Tunable Hydrogen Sulfide Release from Photogenerated Thiobenzaldehydes"],"prefix":"10.1002","volume":"23","author":[{"given":"Zeyun","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Melbourne  Grattan Street Parkville Victoria 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bonnard","sequence":"additional","affiliation":[{"name":"NanoBiotechnology Laboratory Australian Centre for Blood Diseases Monash University  Melbourne Victoria 3004 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Shakouri\u2010Motlagh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Melbourne  Grattan Street Parkville Victoria 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A. 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