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The model systems were based on experimental crystal structures of two types of amyloids: (1)\u2005with aromatic amino acids, and (2)\u2005without aromatic amino acids. Data show that these two types of amyloids have similar interaction energies, supporting experimental findings that aromatic amino acids are not essential for amyloid formation. However, different factors contribute to the stability of these two types of amyloids. In the former, the presence of aromatic amino acids significantly contributes to the strength of interactions between side chains; interactions between aromatic and aliphatic side chains are the strongest, followed by aromatic\u2013aromatic interactions, while aliphatic\u2013aliphatic interactions are the weakest. In the latter, that is, the amyloids without aromatic residues, stability is provided by interactions of aliphatic side chains with the backbone and, in some cases, by hydrogen bonds.<\/jats:p>","DOI":"10.1002\/chem.201701351","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T05:10:55Z","timestamp":1498626655000},"page":"11046-11053","source":"Crossref","is-referenced-by-count":17,"title":["Unexpected Importance of Aromatic\u2013Aliphatic and Aliphatic Side Chain\u2013Backbone Interactions in the Stability of Amyloids"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-6527","authenticated-orcid":false,"given":"Dragan B.","family":"Ninkovi\u0107","sequence":"first","affiliation":[{"name":"Science Program Texas A&amp;M University at Qatar  Texas A&amp;M Engineering Building, Education City Doha Qatar"},{"name":"Innovation Center Department of Chemistry University of Belgrade  Studentski trg 12\u201316 11000 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