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As a virulent factor of <jats:italic>Salmonella typhi<\/jats:italic>, the purified Vi polysaccharide (Vi PS) has become an effective vaccine to combat typhoid fever. The chemical synthesis can provide homogeneous and well\u2010defined molecules for the development of Vi\u2010based vaccines. However, the synthesis of Vi oligosaccharides in high yields and with exclusive \u03b1\u2010stereoselectivities remains very challenging. In this paper, a series of Vi pseudooligosaccharides, including pseudo tetra\u2010, hexa\u2010, and octa\u2010saccharides were efficiently synthesized. These oligosaccharide analogues were conjugated by carbon chain tether through olefin cross metathesis or by the 1,2,3\u2010triazole moiety through copper (I)\u2010catalyzed alkyne\u2013azide cycloaddition reaction (CuAAC). The binding affinities of these oligosaccharide mimics to <jats:italic>anti<\/jats:italic>\u2010Vi antibodies were investigated. These results will be beneficial to the further development of Vi\u2010based oligosaccharide vaccines.<\/jats:p>","DOI":"10.1002\/chem.201702114","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T13:22:44Z","timestamp":1497619364000},"page":"10670-10677","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis and Antigenic Evaluation of Oligosaccharide Mimics of Vi Antigen from <i>Salmonella typhi<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Gao\u2010Lan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengman","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanjun","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De\u2010Cai","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-506X","authenticated-orcid":false,"given":"Xin\u2010Shan","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University  Xue Yuan Road No. 38 Beijing 100191 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)44360-6"},{"key":"e_1_2_7_2_1","unstructured":"\u00a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)82210-7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol048963g"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/iai.29.2.539-544.1980","volume":"29","author":"Szewczyk B.","year":"1980","journal-title":"Infect. 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