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Here, we employ a coarse grain model to investigate the aggregation of 75mer A\u03b2<jats:sub>42<\/jats:sub> oligomers and the salt effect, the cornerstone of fibril evolution. We find that the oligomer morphologies generated by seventy\u2010five monomers or mixed by both fifty monomers and five preset pentameric nuclei are different (spherical vs. bar\u2010\/disk\u2010shaped) and are characterize by a full of coil content (former) and &gt;70\u2009% \u03b2\u2010turn content (latter), indicating a novel role of the nuclei played in the early aggregation stage. The aggregation for the former oligomer adopts a master\u2010nucleus mechanism, whereas for the latter combination of monomers and pentamers a multi\u2010nuclei one is found. The random salt ions will distribute around the aggregates to form several ion shells as the aggregation develops. A unique two\u2010fold gap between the shells is observed in the system containing 100\u2005m<jats:sc>m<\/jats:sc> NaCl, endowing the physiological salt concentration with special implications. Meanwhile, an accurate ion\u2013solute cutoff distance (0.66\u2005nm) is predicted, and recommended to apply to many other aggregated biomolecular systems. The present distribution scenario of ions can be generalized to other aggregated systems, although it is strictly dependent on the identity of a specific aggregate, such as its charge and composition.<\/jats:p>","DOI":"10.1002\/chem.201702388","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T07:22:41Z","timestamp":1502263361000},"page":"16257-16273","source":"Crossref","is-referenced-by-count":5,"title":["Bead\u2010Level Characterization of Early\u2010Stage Amyloid\u2005\u03b2<sub>42<\/sub> Aggregates: Nuclei and Ionic Concentration Effects"],"prefix":"10.1002","volume":"23","author":[{"given":"Dingkun","family":"Hu","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials School of Chemistry and Chemical Engineering University of Jinan  No. 336, West Road of Nan Xinzhuang Jinan Shandong 250022 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials School of Chemistry and Chemical Engineering University of Jinan  No. 336, West Road of Nan Xinzhuang Jinan Shandong 250022 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hospital in University of Jinan University of Jinan  No. 336, West Road of Nan Xinzhuang Jinan Shandong 250022 P. R. 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