{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:32:33Z","timestamp":1785569553166,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"62","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2017,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With a view to developing a theranostic nanomedicine for targeted drug delivery systems visible by magnetic resonance (MR) imaging, robust metal\u2010free magnetic nanoemulsions (mean particle size less than 20\u2005nm) consisting of a biocompatible surfactant and hydrophobic, low molecular weight 2,2,5\u2010trimethyl\u20105\u2010(4\u2010alkoxy)phenylpyrrolidine\u2010<jats:italic>N<\/jats:italic>\u2010oxyl radicals were prepared in pH\u20057.4 phosphate\u2010buffered saline (PBS). The structure of the nanoemulsions was characterized by electron paramagnetic resonance spectroscopy, and dynamic light scattering and small\u2010angle neutron\u2010scattering measurements. The nanoemulsions showed high colloidal stability, low cytotoxicity, enough reduction resistance to excess ascorbic acid, and sufficient contrast enhancement in the proton longitudinal relaxation time (<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>) weighted MR images in PBS in vitro (and preliminarily in vivo). Furthermore, the hydrophobic anticancer drug paclitaxel could be encapsulated inside the nanoparticles, and the resulting paclitaxel\u2010loaded nanoemulsions were efficiently incorporated into HeLa cells to suppress cell growth.<\/jats:p>","DOI":"10.1002\/chem.201702785","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T02:59:30Z","timestamp":1502938770000},"page":"15713-15720","source":"Crossref","is-referenced-by-count":14,"title":["Preparation of Robust Metal\u2010Free Magnetic Nanoemulsions Encapsulating Low\u2010Molecular\u2010Weight Nitroxide Radicals and Hydrophobic Drugs Directed Toward MRI\u2010Visible Targeted Delivery"],"prefix":"10.1002","volume":"23","author":[{"given":"Kota","family":"Nagura","sequence":"first","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusa","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satori","family":"Moronaga","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Science Osaka University, Toyonaka  Osaka 560-8531 Japan"},{"name":"PRESTO (Japan) Science and Technology Agency, Kawaguchi  Saitama 332-0012 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Shimono","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Shiino","sequence":"additional","affiliation":[{"name":"Biomedical MR Science Center, Shiga University of Medical Science, Seta  Otsu 520-2192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tanigaki","sequence":"additional","affiliation":[{"name":"Shiga Medical Center Research Institute  Moriyama 5-4-30 Shiga 524-8524 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukuru","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shiga University of Medical Science, Seta  Otsu 520-2192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shiga University of Medical Science, Seta  Otsu 520-2192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Noda","sequence":"additional","affiliation":[{"name":"Institute of Quantum Beam Science Ibaraki University  Ibaraki 316-8511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Institute of Quantum Beam Science Ibaraki University  Ibaraki 316-8511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhisa","family":"Kato","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4123-6795","authenticated-orcid":false,"given":"Rui","family":"Tamura","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku  Kyoto 606-8501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906684"},{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200906684"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200903053"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200903053"},{"key":"e_1_2_6_3_1","volume-title":"Magnetic Nanomaterials: Nanomaterials for the Life Sciences, Vol.\u20054","year":"2009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201504185"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00578"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr068445e"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602866"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200602866"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.09.013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201004655"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201004655"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200904885"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200904885"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201201060"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2011.112"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201100562"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201100562"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.24345"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc900214f"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm801278n"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200802453"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200802453"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/la5007296"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.12.018"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6460"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3079829"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja101930d"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2jm16278d"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp301930k"},{"key":"e_1_2_6_25_1","first-page":"837","volume-title":"Handbook of Liquid Crystals: Second Edition, Vol.\u20058","author":"Tamura R.","year":"2014"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC09202G"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp410891s"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00546E"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.06.037"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/la7017488"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100314a029"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/P19880002905"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2015.9738"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.711"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.05.009"},{"key":"e_1_2_6_36_1","first-page":"1965","volume-title":"Encyclopedia of Radicals in Chemistry, Biology and Materials, Vol.\u20054: Polymers and Materials","author":"Bardelang D.","year":"2012"},{"key":"e_1_2_6_37_1","volume-title":"Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology","year":"2005"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/B816878D"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)00170-6"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2007.03.013"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchem.201702785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.201702785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:19:18Z","timestamp":1760264358000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.201702785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":47,"journal-issue":{"issue":"62","published-print":{"date-parts":[[2017,11,7]]}},"alternative-id":["10.1002\/chem.201702785"],"URL":"https:\/\/doi.org\/10.1002\/chem.201702785","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,12]]}}}