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Herein, we designed novel temperature\u2010sensitive, curcumin (Cur)\u2010loaded nanogels for the application of scavenging reactive oxygen species and killing pathogenic bacteria. Photothermal sterilization, different from traditional antibiotics, is a promising and effective treatment for pathogenic bacterial infection. The nanogels were fabricated by using poly(<jats:italic>N<\/jats:italic>\u2010isopropylacrylamide) (a temperature\u2010sensitive hydrogel) to encapsulate poly(3,4\u2010ethylenedioxythiophene) nanoparticles (photothermal agents) and Cur through a reformative precipitation polymerization. When triggered by near\u2010IR light, the Cur\u2010loaded nanogels exhibited high (56.8\u2009%), and excellent temperature\u2010sensitive effects. 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