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Phosphorescent cyclometalated Ir\n                    <jats:sup>III<\/jats:sup>\n                    complexes have emerged as potential anticancer agents. By conjugation of VPA to Ir\n                    <jats:sup>III<\/jats:sup>\n                    complexes through an ester bond, VPA\u2010functionalized cyclometalated iridium(III) complexes\n                    <jats:bold>1\u2009a<\/jats:bold>\n                    \u2013\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    were designed and synthesized. These complexes display excellent two\u2010photon properties, which are favorable for live\u2010cell imaging. The ester bonds in\n                    <jats:bold>1\u2009a<\/jats:bold>\n                    \u2013\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    can be hydrolyzed quickly by esterase and display similar inhibition of HDAC activity to VPA. Notably,\n                    <jats:bold>1\u2009a<\/jats:bold>\n                    \u2013\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    can overcome cisplatin resistance effectively and are about 54.5\u201389.7 times more cytotoxic than cisplatin against cisplatin\u2010resistant human lung carcinoma (A549R) cells. Mechanistic studies indicate that\n                    <jats:bold>1\u2009a<\/jats:bold>\n                    \u2013\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    can penetrate into human cervical carcinoma (HeLa) cells quickly and efficiently, accumulate in mitochondria, and induce a series of cell\u2010death\u2010related events mediated by mitochondria. This study gives insights into the design and anticancer mechanisms of multifunctional anticancer agents.\n                  <\/jats:p>","DOI":"10.1002\/chem.201703157","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T23:32:41Z","timestamp":1503444761000},"page":"15166-15176","source":"Crossref","is-referenced-by-count":50,"title":["Valproic Acid\u2010Functionalized Cyclometalated Iridium(III) Complexes as Mitochondria\u2010Targeting Anticancer Agents"],"prefix":"10.1002","volume":"23","author":[{"given":"Rui\u2010Rong","family":"Ye","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical Engineering Sun Yat-Sen University  Guangzhou 510275 P. R. 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