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This azido\u2010containing conjugate was then anchored to the nanochannels of an alkyne\u2010modified mesoporous silica nanoparticle (MSN) system via copper(I)\u2010catalyzed azide\u2013alkyne cycloaddition. An analogous nanosystem was also prepared by immobilization of a hydrazine\u2010substituted ZnPc to the MSN followed by coupling with Dox. The release of Dox under acidic conditions was studied in phosphate\u2010buffered saline. After internalization into human hepatocellular carcinoma HepG2 cells, these nanoparticles showed fluorescence not only for ZnPc, but also for Dox, suggesting that release of Dox was triggered by the acidic intracellular environment. The chemocytotoxic Dox together with singlet oxygen generated upon irradiation on the encapsulated ZnPc in these MSNs could kill the cells effectively. A synergistic cytotoxicity was suggested by a less\u2010than\u2010unity combination index. These nanoparticles function as both nanophotosensitizers for photodynamic therapy and as nanoplatforms for pH\u2010controlled drug release.<\/jats:p>","DOI":"10.1002\/chem.201703188","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T16:29:22Z","timestamp":1501777762000},"page":"16505-16515","source":"Crossref","is-referenced-by-count":55,"title":["Encapsulating pH\u2010Responsive Doxorubicin\u2013Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy"],"prefix":"10.1002","volume":"23","author":[{"given":"Roy C. H.","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Chemistry The Chinese University of Hong Kong, Shatin, N.T.  Hong Kong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-960X","authenticated-orcid":false,"given":"Dennis K. 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