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Here, the recently developed reagent\u2014CF<jats:sub>2<\/jats:sub>HCHN<jats:sub>2<\/jats:sub>\u2014selectively esterifies carboxyl groups on organic molecules in the presence of other polar functional groups. The reaction is remarkably simple, proceeding at room temperature in chloroform without addition of a catalyst. The procedure allows \u201clast\u2010step\u201d incorporation of a fluorinated ester moiety into organic structures, including bioorganic molecules such as peptides and proteins. The fluorinated ester can subsequently function as a <jats:sup>19<\/jats:sup>F\u2010probe in biomolecules, thereby enabling molecular size determination by diffusion <jats:sup>19<\/jats:sup>F\u2005NMR experiments.<\/jats:p>","DOI":"10.1002\/chem.201703446","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T08:56:38Z","timestamp":1501232198000},"page":"13279-13283","source":"Crossref","is-referenced-by-count":30,"title":["Selective <sup>19<\/sup>F\u2010Labeling of Functionalized Carboxylic Acids with Difluoromethyl Diazomethane (CF<sub>2<\/sub>HCHN<sub>2<\/sub>)"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1821-9011","authenticated-orcid":false,"given":"Pavel K.","family":"Mykhailiuk","sequence":"first","affiliation":[{"name":"Taras Shevchenko National University of Kyiv Chemistry Department  Volodymyrska 64 01601 Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kishko","sequence":"additional","affiliation":[{"name":"Taras Shevchenko National University of Kyiv Chemistry Department  Volodymyrska 64 01601 Kyiv Ukraine"},{"name":"Enamine Ltd.  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