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Herein, a facile and versatile strategy for preparing functional multiblock copolymers composed of sequential peptides and well\u2010defined vinyl polymers with a narrow polydispersity is reported. Cyclic oligopeptides have been developed that contain an alkoxyamine bond in the framework. By using this type of cyclic initiator, peptide\u2010containing multiblock copolymers are successfully synthesized by nitroxide\u2010mediated polymerization of styrene. To demonstrate the versatility of this method, radical (co)polymerizations were carried out for different monomers (<jats:italic>p<\/jats:italic>\u2010chlorostyrene, 4\u2010vinylpyridine, and styrene\/acrylonitrile) and by three different cyclic peptide initiators with specific amino acid sequences. The resultant multiblock copolymer is foldable through intramolecular interactions between peptide blocks. It is believed that this approach will significantly advance the field of controlled polymer synthesis for complex structures and single\u2010chain folding.<\/jats:p>","DOI":"10.1002\/chem.201703655","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T07:08:44Z","timestamp":1502348924000},"page":"15050-15058","source":"Crossref","is-referenced-by-count":19,"title":["Facile Synthesis of Multiblock Copolymers Containing Sequence\u2010Controlled Peptides and Well\u2010Defined Vinyl Polymers by Nitroxide\u2010Mediated Polymerization"],"prefix":"10.1002","volume":"23","author":[{"given":"Shin\u2010nosuke","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Molecular Chemistry &amp; Biochemistry Faculty of Science &amp; Engineering Doshisha University  Kyotanabe, Kyoto 610-0321 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Molecular Chemistry &amp; Biochemistry Faculty of Science &amp; Engineering Doshisha University  Kyotanabe, Kyoto 610-0321 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Molecular Chemistry &amp; Biochemistry Faculty of Science &amp; Engineering Doshisha University  Kyotanabe, Kyoto 610-0321 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